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ProteomicsUBA80 and UBA52 regulate DNA damage repair by targeting RNF168-dependent ubiquitination of H2A/H2AX
Tandem affinity purification of RNF168 and various RNF168 mutants to identify interacting proteins involved in DNA damage repair.
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD037840 | Pride
Dna damage Rnf168 Ubiquitin 
ProteomicsCrosslinking RNF168(1-113) to Nucleosome core particels
The project aimed to identify interaction sites of RNF168 with the Nucleosomes. RNF168 interaction with the Nucleosome was probed by BS3 crosslinking to support structure modeling based on NMR and mutagenesis experiments
ORGANISM(S): Homo sapiens (Human) 
2019-04-02 | PXD012723 | Pride
Rnf168 Nucleosome Xl-ms 
ProteomicsUBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168
Maintenance of genome integrity requires tight control of DNA damage signalling and repair activities at DNA lesions, as well as their restriction at telomeres. Key components of the mechanisms underlying appropriate responses to DNA damage include phosphorylation events by DNA damage response (DDR)...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-30 | PXD044410 | Pride
Molecular biology Non-homologous-end joining Rnf168 Dna damage and repair Ube2d3 Lc-msms Telomere 
GenomicsGenome wide expression change by RNF168 knocking down in NEC cells
Genome wide expression change by RNF168 knocking down in NEC cells
PRJNA485964 | ENA
GenomicsGenome wide expression change by RNF168 knocking down in MCF-7 cells
Genome wide expression change by RNF168 knocking down in MCF-7 cells
PRJNA417460 | ENA
TranscriptomicsGenome wide expression change by RNF168 knocking down in NEC cells
We aim to the investigate the role of RNF168 in breast cancer progression. NEC cells were used as the model and RNF168 was silenced by siRNA.
ORGANISM(S): Homo sapiens 
2019-01-11 | GSE118532 | GEO
TranscriptomicsGenome wide expression change by RNF168 knocking down in MCF-7 cells
We aim to the investigate the role of RNF168 in breast cancer progression. MCF-7 cells were used as the model and RNF168 was silenced by siRNA.
ORGANISM(S): Homo sapiens 
2018-11-07 | GSE106617 | GEO
UnknownMechanisms of RNF168 nucleosome recognition and ubiquitylation.
Not available
S-EPMC10939898 | biostudies-literature
UnknownA PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis.
Not available
S-EPMC7204040 | biostudies-literature
UnknownHistone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination.
Not available
S-EPMC7235047 | biostudies-literature
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