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ProteomicsMolecular Basis of Kv1 Channel Downregulation and Its Epileptogenic Implications in Lgi1 Knock-out Mice
The Kv1 members (KCNA, Shaker) of the voltage-gated potassium channels are implicated in determining key functional neuronal properties from spike generation at axonal initial segments to the control of synaptic strength at nerve terminals. In animal models of LGI1-dependent autosomal dominant late...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-03 | PXD043649 | Pride
Lgi1 Kv1 Interactome 
ProteomicsPatient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1
Autoantibodies against leucine-rich glioma-inactivated 1 (LGI1) occur in patients with encephalitis who present with frequent focal seizures and a pattern of amnesia consistent with focal hippocampal damage. To investigate whether the cellular and subcellular distribution of LGI1 may explain the loc...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-10 | PXD032712 | Pride
Auto-antibodies Limbic encephalitis Autosomal-dominant lateral temporal lobe epilepsy (adlte) Kv1 channels Leucin-rich glioma inactivated 1 (lgi1) Adam 
TranscriptomicsExpression data from homozygous deletion of the Lgi1 gene in murine neural precursor-like cells
The hypercellularity in the outer layers of the cortex in Lgi1 null mice suggested that Lgi1 possibly plays a role in controlling cell migration dynamics. To investigate this hypothesis, we first generated and immortalized neural precursor-like cells (NPC), isolated from Lgi1 null and wild type mice...
ORGANISM(S): Mus musculus 
2013-08-01 | GSE49145 | GEO
GenomicsWolbachia endosymbiont of Kradibia gibbosae strain:MIAO-Lgi1
Wolbachia endosymbiont of Kradibia gibbosae strain:MIAO-Lgi1 Genome sequencing and assembly
PRJNA637962 | ENA
TranscriptomicsExpression data from homozygous deletion of the Lgi1 gene in murine neural precursor-like cells
The hypercellularity in the outer layers of the cortex in Lgi1 null mice suggested that Lgi1 possibly plays a role in controlling cell migration dynamics. To investigate this hypothesis, we first generated and immortalized neural precursor-like cells (NPC), isolated from Lgi1 null and wild type mice...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-49145 | biostudies-arrayexpress
UnknownLGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis.
Not available
S-EPMC6156957 | biostudies-literature
UnknownBiallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1-ADAM22/23 pathway.
Not available
S-EPMC12493049 | biostudies-literature
UnknownIdentification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1-LGI1 signaling.
Not available
S-EPMC4947863 | biostudies-literature
UnknownLGI1 encephalitis: potentially complement-activating anti-LGI1-IgG subclasses 1/2/3 are associated with the development of hippocampal sclerosis.
Not available
S-EPMC11377613 | biostudies-literature
UnknownObjective sleep profile in LGI1/CASPR2 autoimmunity.
Not available
S-EPMC8842336 | biostudies-literature
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