We have used a lipoprotein-deficient mutant Streptococcus pneumoniae strain, delta lgt, to investigate the role of lipoproteins during inflammatory responses to live S. pneumoniae.
This project detected the protein composition of extracellular vesicles (EV) produced by S. aureus WT JE2 strain and its lgt mutant (lipoprotein deficient mutant). Our recent study found that mutation of lgt in S. aureus USA300 JE2 strain significantly increased EV production in S. aureus and decrea...
Comparison of the immune response of human whole blood to lipoteichoic acid (LTA) derived from the Staphylococcus aureus SA113 delta-lgt mutant (lacks lipoproteins), LTA from S. aureus SA113 wt. and PAM2Cys, a lipoprotein analogue. Background: Our goal was to expand our report that LTA from SA 113 w...
This project investigated the role of lipoproteins in immune signaling by the model probiotic Lactobacillus plantarum, by mutagenesis of the prolipoprotein diacylglyceryltransferase encoding lgt gene involved in lipoprotein acylation.
