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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
TranscriptomicsTranscription profiling of male Fech mutant BALB/c mouse livers vs male control BALB/c livers
Comparison of gene expression in livers of male Fech mutant BALB/c mouse with livers of male control BALB/c
ORGANISM(S): Mus musculus 
2005-10-14 | E-MEXP-189 | biostudies-arrayexpress
TranscriptomicsTargeting c-MYC by antagonizing PP2A inhibitors in breast cancer
Inhibition of SET by siRNA or SET antagonist and CIP2A by siRNA can downregulate c-MYC and c-MYC target genes. Cells were treated with a SET antagonist (1μMOP449) for 12 hours, or siRNA for 48 hours.
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-58008 | biostudies-arrayexpress
MetabolomicsMetabolomic profiling of Campylobacter jejuni with resistance gene ermB by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry and tandem quadrupole mass spectrometry
The metabolome changes of Campylobacter jejuni with resistant gene ermB remain unclear. Here, we described an untargeted metabolomic workflow based on ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry to investigate the metabolites perturbations mediated by erm...
2018-08-07 | MTBLS496 | MetaboLights
TranscriptomicsTranscription profiling of 4 week old BALB/c_Fech m1Pas mice (Fech) vs with 4 week old control BALB/c mice
Comparison of liver gene expression of 4 week old BALB/c_Fech m1Pas mice(Fech mice for short) with 4 week old control BALB/c mice.
ORGANISM(S): Mus musculus 
2005-10-21 | E-MEXP-194 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of the host cutaneous response to Ixodes scapularis
Introduction: Ixodes scapularis ticks are hematophagous arthropods capable of transmitting many infectious agents to humans. The process of blood feeding is an extended and continuous interplay between tick and host responses. While this process has been studied extensively in vitro, no global under...
ORGANISM(S): Mus musculus 
2012-02-17 | E-GEOD-33345 | biostudies-arrayexpress
ProteomicsSystematic evaluation and modulation of HLA class I downregulation in Merkel cell carcinoma
Lee PC, Klaeger S, Le PM, Korthauer K, Cheng J, Wong A, Tarren A, Lemvigh C, Sarkizova S, Li L, Frost TC, Nomburg J, Liu X, Pomerance L, Doherty L, Witten E, Zhang W, Apffel A, Wallace L, Neuberg D, Olsen L, Thakuria M, Clauser K, Starrett G, Doench J, Buhrlage SJ, Carr SA, DeCaprio JA, Wu CJ, Keski...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-20 | MSV000087251 | MassIVE
UnknownDouble Nitrogenation Layer Formed Using Nitric Oxide for Enhancing Li+ Storage Performance, Cycling Stability, and Safety of Si Electrodes.
Not available
S-EPMC11220681 | biostudies-literature
GenomicsTE-associated chromatin variation in mice livers
Chromatin accessibility is a hallmark of active regulatory function in the genome and variation of chromatin accessibility across individuals has been shown to contribute to complex traits and disease susceptibility. However, the mechanisms responsible for chromatin variation among different individ...
ORGANISM(S): Mus musculus 
2016-07-14 | E-GEOD-75770 | biostudies-arrayexpress
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