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TranscriptomicsRNAi profiling of human fascin knockdown esophageal squamous carcinoma cells
Fascin, an actin-binding protein, is upregulated in a variety of cancers, including esophageal squamous cell carcinoma (ESCC) and is proposed to function in cellular growth, mobility and invasiveness. Nonetheless, the molecular mechanisms through which fascin expression contributes to the proliferat...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-11373 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of human ezrin-knockdown ec109 cells(PSE1) and control(PS)
Ezrin belongs to the ezrin¨Cradixin¨Cmoesin (ERM) family proteins, which cross-link actin cytoskeleton and plasma membrane, and is actively involved in regulating the growth and metastatic capacity of cancer cells. Esophageal squamous cell carcinoma (ESCC) is one of the most fatal malignancies in ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6233 | biostudies-arrayexpress
ProteomicsSILAC experiments profiling of the proteome of WT and CobB KO E.coli
SILAC experiments profiling of the proteome of WT and CobB KO E.coli
ORGANISM(S): Escherichia Coli 
2021-12-11 | PXD030345 |
ProteomicsSILAC experiments profiling of the proteome of WT and YiaC KO E.coli
SILAC experiments profiling of the proteome of WT and YiaC KO E.coli
ORGANISM(S): Escherichia Coli 
2021-12-11 | PXD030346 |
TranscriptomicsGene expression profile for NGAL overexpression in esophageal squamous carcinoma cell
Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3, uterocalin, siderocalin or lipocalin 2 (Lcn2), is a member of the lipocalin family. Elevated NGAL involves various functions in malignant cells, even sometimes the conclusions were controversial. NGAL inhibits apoptosis ...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-57630 | biostudies-arrayexpress
TranscriptomicsGene expression profile for SMYD3 knockdown in esophageal squamous carcinoma cell
SET (Su) and MYND (myeloid-Nervy-DEAF-1) domain-containing protein (SMYD) is a methyltransferase family, including five members of which SMYD1, SMYD2, SMYD3 and SMYD4, has been found to play critical roles in human carcinogenesis. It has been demonstrated that the altered expression of SMYD3 is asso...
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-85419 | biostudies-arrayexpress
ProteomicsProteome-wide Hyposuccinylation of Esophageal Squamous Cell Cancer to Promotion of Tumor Metabolism and Migration
We identify abnormal protein and post-translational modification (PTM) pathways, including significantly downregulated lysine succinylation sites in cancer cells. Focusing on hyposuccinylation, we reveal that this altered PTM was enriched on enzymes of metabolic pathways inextricably linked with can...
ORGANISM(S): Homo Sapiens 
2020-09-18 | PXD021567 |
ProteomicsHistone PTMs dataset for Hyposuccinylation Derived from Abnormal Metabolism Promotes the Cell Migration of Esophageal Squamous Cell Cancer
We identify abnormal protein and post-translational modification (PTM) pathways, including many downregulated lysine succinylation sites in cancer cells. Focusing on hyposuccinylation, we reveal that this altered PTM was enriched on enzymes of metabolic pathways and the reduced succinyl-CoA may lead...
ORGANISM(S): Homo Sapiens 
2020-09-26 | PXD021700 |
MetabolomicsSensing Ceramides by CYSLTR2 and P2RY6 to Aggravate Atherosclerosis

Recent evidence shows elevated circulating long-chain ceramide levels predicts atherosclerotic cardiovascular disease (ASCVD) independently of cholesterol. Although targeting ceramides signaling may provide therapeutic benefits beyond the treatment of hypercholesterolemia, the underlying mechanis...

2025-04-15 | MTBLS11925 | MetaboLights
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