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ProteomicsClinically Relevant Aβ42 Stereochemistry-Driven Proteome Perturbation, Aggregation Crosstalk and Cytotoxicity Inhibition: ABPP
The stereochemical modification of Aβ42 discovered in the clinical samples of Alzheimer's disease (AD) patients has attracted increasing attention. However, most existing studies have focused on the characteristic analysis of a single isomer, ignoring the complex interactions of the coexistence of m...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-20 | PXD065394 | Pride
Aβ42  alzheimer's disease  stereoisomeric modification  crosstalk effect  amyloid protein aggregation  neurotoxicity  abpp 
ProteomicsProteomics results of rice seeds
To explore the isomerization levels of proteins in the seed, we performed a mass spectrometry-based proteomics analysis of the seed samples from the Nip and Daat1 groups. We achieved a robust workflow with high proteome depth, quantifying 1925 nip and 1868 Daat1 proteins, of which 1702 were shared p...
ORGANISM(S): Oryza sativa (Rice) 
2026-02-20 | PXD059692 | Pride
Rice  seed  lcms 
ProteomicsClinically Relevant Aβ42 Stereochemistry-Driven Proteome Perturbation, Aggregation Crosstalk and Cytotoxicity Inhibition: Cytotoxicity
The stereochemical modification of Aβ42 discovered in the clinical samples of Alzheimer's disease (AD) patients has attracted increasing attention. However, most existing studies have focused on the characteristic analysis of a single isomer, ignoring the complex interactions of the coexistence of m...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-20 | PXD065373 | Pride
Aβ42  alzheimer's disease  stereoisomeric modification  crosstalk effect  amyloid protein aggregation  neurotoxicity  abpp 
ProteomicsDisulfide Bond Shuffling Induces Molecular Crosstalk: Delayed Insulin Aggregation and Enhanced Neurotoxicity
Our study explores the novel concept of disulfide bond shuffling-provoked oligomer crosstalk in insulin. We demonstrate that this dynamic process not only modulates the aggregation kinetics of insulin but also significantly influences its cytotoxic potential. Through a combination of biophysical tec...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-23 | PXD053868 | Pride
Disulfide Neurotoxicity Ion mobility-mass spectrometry Disulfide bond shuffling Insulin 
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