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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
UnknownThree dimensional collagen scaffolds promote iPSC induction with higher pluripotency.
Not available
S-EPMC5084158 | biostudies-literature
UnknownEvery road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes.
Not available
S-EPMC9006546 | biostudies-literature
UnknownThe effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies.
Not available
S-EPMC6538583 | biostudies-literature
ProteomicsHigh-Throughput Intact Glycopeptide Quantification Strategy with Targeted-MS (HTiGQs-Target) Reveals Site-Specific IgG N-Glycopeptides as Biomarkers for Hepatic Disorder Diagnosis and Staging
We developed a high-throughput targeted quantification strategy for intact glycopeptides (HTiGQs-Target) to diagnose and differentiate the malignancy of liver diseases. The method involves two-step labeling. This step derivatization makes the same parent ions in different samples produce sufficient ...
ORGANISM(S): Homo Sapiens 
2023-05-30 | PXD042528 |
ProteomicsComprehensive N-Glycomics Profiling of Urinary Extracellular Vesicles Identifies a Novel Biomarker Panel for Diagnosis of Bladder Cancer
Bladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges.Urinary extracellular vesicles (EVs) is a particularly promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. We investigate bioma...
ORGANISM(S): Homo Sapiens 
2024-11-14 | PXD057882 |
UnknownHuman umbilical cord mesenchymal stem cells restore the ovarian metabolome and rescue premature ovarian insufficiency in mice.
Not available
S-EPMC7641864 | biostudies-literature
ProteomicsN-glycopeptide Signatures in Liver Diseases
(1) A N-glycopeptide method based on 18O/16O C-terminal labelling to obtain comparisons of serum from patients with HBV-related hepatocellular carcinoma (HCC-O18 labelling) and HBV-related liver cirrhosis (LC-O16 labelling) (2) MRM verification of N-glycopeptide alterations
ORGANISM(S): Homo Sapiens 
2019-09-10 | PXD013586 |
ProteomicsIntensive lifestyle intervention modulates white adipose glycolipid metabolism via protein acetylation associated with Ep300
The homeostatic regulation of white adipose tissue (WAT) is crucial for maintain energy and metabolism balance. Plenty of clinical trials proved that intensive lifestyle intervention (ILI) improved fat accumulation in patients with obesity. Yet the underlying acetylated regulations of WAT during ILI...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-02 | PXD046768 | Pride
White adipose tissue  acetylation modification  obesity  intensive lifestyle intervention  ep300 
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