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Reactivation of varicella-zoster virus (VZV) causes herpes zoster (HZ) in humanity and elicits VZV-specific immune response. Yet the impact of VZV on host proteins post-translational modifications (PTMs) remains largely untapped. In this study, we investigated the global changes of phosphorylation l...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD058933 | Pride
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
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