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ProteomicsThe oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma, a lethal disease lacking specific therapies. This study reports on the identification, characterization, and immunotherapeutic application of HLA-presented neoantigens specific for the DNAJB1-PRKAC...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD029882 | Pride
Cancer Hla ligands Mass spectrometry Fibrolamellar hepatocellular carcinoma Immunopeptidomics Fl-hcc 
TranscriptomicsRecurrent activating mutation in PRKACA in cortisol-producing adrenal tumors
We performed mRNA-seq of a PRKACA-mutant adrenal tumor and demonstrated that the mutation is expressed at the mRNA level. Total RNA obtained from a cortisol-producing adrenal tumor with a PRKACA p.Leu206Arg mutation.
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-56016 | biostudies-arrayexpress
GenomicsEffects of fibrolamellar carcinoma-associated DNAJB1-PRKACA in HEK293T cells
Effects of fibrolamellar carcinoma-associated DNAJB1-PRKACA in HEK293T cells
PRJNA679841 | ENA
ProteomicsPresentation of DNAJB1-PRKACA fusion neoantigens by different HLA class I alleles
Fibrolamellar carcinoma (FLC) is a liver tumor with a high mortality burden and few treatment options. A promising therapeutic vulnerability in this disease is its highly conserved driver mutation: a gene fusion between DNAJB1 and PRKACA, which is expressed in virtually all FLC tumors and could be a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042316 | Pride
Fusion neoantigens Hla class i Cd8 t cell Dnajb1-prkaca Fibrolamellar carcinoma 
GenomicsSingle cell RNA-seq and TCR-seq of T cell responses against DNAJB1-PRKACA
Single cell RNA-seq and TCR-seq of T cell responses against DNAJB1-PRKACA
PRJNA865298 | ENA
ProteomicsIncreased activity of protein kinase A, even without DNAJB1, is sufficient to cause Fibrolamellar hepatocellular carcinoma
Most fibrolamellar carcinoma (FLC) is driven by a fusion of DNAJB1 and PRKACA, the catalytic subunit of protein kinase A (PKA). PKA holoenzyme activity is controlled through a regulatory protein (R) that both inhibits and localizes catalytic activity. An excess of regulatory subunits ensures PRKACA ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-17 | PXD043816 | Pride
Liver cancer Tumorigenesis Fusion oncoprotein Childhood cancer Adolescent and young adult cancer Protein kinase a Fibrolamellar carcinoma 
TranscriptomicsSingle cell RNA-seq and TCR-seq of T cell responses against DNAJB1-PRKACA
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma (FL-HCC), a lethal disease lacking specific therapies. Here, we report on the identification, characterization and first immunotherapeutic application of HLA-presented neoantigens specific for the D...
ORGANISM(S): Homo sapiens 
2022-09-12 | GSE210337 | GEO
TranscriptomicsRecurrent activating mutation in PRKACA in cortisol-producing adrenal tumors
We performed mRNA-seq of a PRKACA-mutant adrenal tumor and demonstrated that the mutation is expressed at the mRNA level.
ORGANISM(S): Homo sapiens 
2014-04-15 | GSE56016 | GEO
UnknownGenotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.
Not available
S-EPMC8551059 | biostudies-literature
UnknownTherapeutic, Clinicopathological, and Molecular Correlates of PRKACA Expression in Gastrointestinal Cancers.
Not available
S-EPMC11510541 | biostudies-literature
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