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ProteomicsThe oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma, a lethal disease lacking specific therapies. This study reports on the identification, characterization, and immunotherapeutic application of HLA-presented neoantigens specific for the DNAJB1-PRKAC...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD029882 | Pride
Cancer Hla ligands Mass spectrometry Fibrolamellar hepatocellular carcinoma Immunopeptidomics Fl-hcc 
GenomicsEffects of fibrolamellar carcinoma-associated DNAJB1-PRKACA in HEK293T cells
Effects of fibrolamellar carcinoma-associated DNAJB1-PRKACA in HEK293T cells
PRJNA679841 | ENA
GenomicsSingle cell RNA-seq and TCR-seq of T cell responses against DNAJB1-PRKACA
Single cell RNA-seq and TCR-seq of T cell responses against DNAJB1-PRKACA
PRJNA865298 | ENA
ProteomicsPresentation of DNAJB1-PRKACA fusion neoantigens by different HLA class I alleles
Fibrolamellar carcinoma (FLC) is a liver tumor with a high mortality burden and few treatment options. A promising therapeutic vulnerability in this disease is its highly conserved driver mutation: a gene fusion between DNAJB1 and PRKACA, which is expressed in virtually all FLC tumors and could be a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042316 | Pride
Fusion neoantigens Hla class i Cd8 t cell Dnajb1-prkaca Fibrolamellar carcinoma 
TranscriptomicsSingle cell RNA-seq and TCR-seq of T cell responses against DNAJB1-PRKACA
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma (FL-HCC), a lethal disease lacking specific therapies. Here, we report on the identification, characterization and first immunotherapeutic application of HLA-presented neoantigens specific for the D...
ORGANISM(S): Homo sapiens 
2022-09-12 | GSE210337 | GEO
ProteomicsDistinct phases of cellular signaling revealed by time-resolved protein synthesis
The post-translational regulation of protein function is involved in most cellular processes. As such, synthetic biology tools that operate at this level provide opportunities for manipulating cellular states. Here, we deploy a proximity-triggered protein trans-splicing technology to enable the time...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-10-06 | PXD044530 | Pride
Signaling Silac ap-ms Protein engineering Prm Tmt-phosphoproteomics Fusion oncogenes 
ProteomicsIncreased activity of protein kinase A, even without DNAJB1, is sufficient to cause Fibrolamellar hepatocellular carcinoma
Most fibrolamellar carcinoma (FLC) is driven by a fusion of DNAJB1 and PRKACA, the catalytic subunit of protein kinase A (PKA). PKA holoenzyme activity is controlled through a regulatory protein (R) that both inhibits and localizes catalytic activity. An excess of regulatory subunits ensures PRKACA ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-17 | PXD043816 | Pride
Liver cancer Tumorigenesis Fusion oncoprotein Childhood cancer Adolescent and young adult cancer Protein kinase a Fibrolamellar carcinoma 
GenomicsDNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming
DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming
PRJNA1106454 | ENA
TranscriptomicsDNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming
Fibrolamellar carcinoma (FLC) is a liver cancer of adolescents and young adults defined by fusion of the DNAJB1 heat shock protein and protein kinase A (PKA) catalytic subunit (DNAJB1-PRKACA). The resulting chimeric protein has increased kinase activity and is essential for FLC xenograft growth. How...
ORGANISM(S): Homo sapiens 
2024-09-08 | GSE266253 | GEO
TranscriptomicsEffects of fibrolamellar carcinoma-associated DNAJB1-PRKACA in HEK293T cells
Fibrolamellar carcinoma (FLC) is a type of primary liver cancer that commonly arises in adolescents and young adults in a background of normal liver tissue and has an overall poor prognosis due to lack of effective chemotherapeutic agents. The DNAJB1-PRKACA gene fusion (DP) has been reported in the ...
ORGANISM(S): Homo sapiens 
2022-04-05 | GSE161932 | GEO
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