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ProteomicsDe novo designed protein guiding targeted protein degradation
Targeted protein degradation is a powerful tool for biological research, cell therapy, and synthetic biology. However, conventional methods often depend on pre-fused degrons or chemical degraders, limiting their wider applications. In this study, a guided protein labeling and degradation system (GPl...
ORGANISM(S): Escherichia coli 
2025-07-05 | PXD063956 | Pride
Protein degradation  protein design 
UnknownRegulation of cashmere fineness traits by noncoding RNA in Jiangnan cashmere goats.
Not available
S-EPMC10566132 | biostudies-literature
UnknownEffect of the FA2H Gene on cashmere fineness of Jiangnan cashmere goats based on transcriptome sequencing.
Not available
S-EPMC9306159 | biostudies-literature
ProteomicsPolianthes tuberosa L. Extract Suppresses Melanogenesis through Concurrent Inhibition of cAMP/CREB and MAPK Signaling Pathways
Ultraviolet (UV) radiation is a primary environmental stimulus for skin hyperpigmentation. Polianthes tuberosa L. (PT), rich in polyphenols and flavonoids, possesses antioxidant and anti-inflammatory properties, yet the anti-melanogenic mechanism of the PT extract (PTE) remains unexplored. Network p...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-16 | PXD072752 | Pride
Anti-melanogenesis  hyperpigmentation  mechanistic study  oxidative stress  polianthes tuberosa l. flower 
UnknownEfficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell cytochrome P450 CYP107D1 biocatalyst.
Not available
S-EPMC10722395 | biostudies-literature
UnknownCRISPR/Cpf1-FOKI-induced gene editing in Gluconobacter oxydans.
Not available
S-EPMC10980938 | biostudies-literature
UnknownProcessing milk causes the formation of protein oxidation products which impair spatial learning and memory in rats.
Not available
S-EPMC9066704 | biostudies-literature
UnknownScreening of ent-copalyl diphosphate synthase and metabolic engineering to achieve de novo biosynthesis of ent-copalol in Saccharomyces cerevisiae.
Not available
S-EPMC11253141 | biostudies-literature
UnknownPSAT1 enhances the efficacy of the prognosis estimation nomogram model in stage-based clear cell renal cell carcinoma.
Not available
S-EPMC11016215 | biostudies-literature
UnknownProtective Effects and Mechanisms of Vaccarin on Vascular Endothelial Dysfunction in Diabetic Angiopathy.
Not available
S-EPMC6769517 | biostudies-literature
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