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ProteomicsNovel SLCO2B1 mRNA isoform acts as a noncoding RNA and drives cancer progression through FMR1-mediated protein biosynthesis
The eukaryotic 5’ untranslated region (5’ UTR) canonically influences mRNA translation efficiency. However, the role of the 5’ UTR structure in blocking mRNA translation and turning a coding RNA into a noncoding RNA remains undocumented. Herein, we discovered a novel mRNA isoform of the human solute...
ORGANISM(S): Homo Sapiens 
2025-11-27 | PXD071347 |
ProteomicsThe proteins detection in the Early Stage of Myocardial Infarction
Eight-week-old mice were divided into six groups: sham group, 10min after MI, 1h after MI, 6h after MI, 24h after MI and 72h after MI. Myocardial infarction was performed by ligating the proximal left anterior descending coronary artery. Then the infarction myocardial tissue was taken for DIA protei...
ORGANISM(S): Mus Musculus 
2020-07-05 | PXD020193 |
ProteomicsCRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription
The RNA helicase DDX41 is a DEAD-box helicase that is well known as a virus sensor in dendritic cells and a tumor suppressor that is frequently mutated in myeloid neoplasms. However, the functions and relevance of DDX41 in solid tumors remain largely unexplored. In this study, through in vivo CRISPR...
ORGANISM(S): Homo Sapiens 
2024-12-23 | PXD059178 |
ProteomicsA Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract
A Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract
ORGANISM(S): Mus Musculus 
2025-08-25 | PXD067684 |
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