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TranscriptomicsPancreatic islet expression profiling in diabetes prone C57BLKS/J mice vs C57BL6/J mice.
C57BLKS/J mice are susceptible to diabetes, because of islet dysfunction, whereas C57BL6/J mice are not. Differences in gene expression between the two strains may account for this sensitivity. Furthermore these differences may only be evident in the hyperstimulated (diabetic or hyperglycemic) state...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-11257 | biostudies-arrayexpress
UnknownSynchronous choroid plexus papilloma and Wilms tumor in a girl, disclosing a Li-Fraumeni syndrome.
Not available
S-EPMC7789227 | biostudies-literature
ProteomicsMacrophages promote collagen fibrillogeneis through modulation of fibroblast circadian rhythms
Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another is unknown. Here, we reveal that macrophage-fibroblast interaction enhances collagen deposition which...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD061123 | Pride
Thp1 Circadian rhythm Polarisation Macrophages Collagen Secretome 
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
UnknownChmp 1A is a mediator of the anti-proliferative effects of all-trans retinoic acid in human pancreatic cancer cells.
Not available
S-EPMC3152783 | biostudies-literature
UnknownGenetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy.
Not available
S-EPMC6613726 | biostudies-literature
UnknownThymidine Phosphorylase Deficiency or Inhibition Preserves Cardiac Function in Mice With Acute Myocardial Infarction.
Not available
S-EPMC10122909 | biostudies-literature
TranscriptomicsExpression data from Arabidopsis thaliana root protoplast
BACKGROUND:Dynamic transcriptional regulation is critical for an organism's response to environmental signals and yet remains elusive to capture. Such transcriptional regulation is mediated by master transcription factors (TF) that control large gene regulatory networks. Recently, we described a dyn...
ORGANISM(S): Arabidopsis thaliana 
2016-02-08 | E-GEOD-69389 | biostudies-arrayexpress
MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
UnknownCulture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers.
Not available
S-EPMC9746806 | biostudies-literature
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