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ProteomicsComparing the plasma membrane proteins of Nek1+/+ and Nek1Kat2J/Kat2J MEFs
Mass spectrometry data comparing the plasma membrane proteins of Nek1-WT and Nek1-Kat2J MEFs enriched by Pierce™ Cell Surface Protein Isolation Kit.
ORGANISM(S): Mus musculus (Mouse) 
2021-08-06 | PXD027493 | Pride
Nek1 Plasma membrane proteins Retromer 
MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
ProteomicsDistinct functions of RIPK1 ubiquitination in regulating its activation mediated by TNFR1 and TLRs signaling
We identified and quantified ubiquitination sites of WT RIPK1 and K627R mutant in TNF signaling pathway and 293T overexpression system
ORGANISM(S): Homo Sapiens Mus Musculus 
2020-10-23 | PXD022157 |
ProteomicsQuantitative analysis of phosphoproteome in necroptosis
we conducted a systemic quantitative analysis of phosphoproteome regulated by RIPK1 kinase across a time course from complex I to complex IIb formation during necroptosis of FADD deficient Jurkat cells induced by TNFα
ORGANISM(S): Homo Sapiens 
2021-04-12 | PXD025313 |
ProteomicsIdentification of TRADD phosphorylation sites
We re-introduced Flag-mTRADD into Tradd-/- MEFs, and identified the phosphorylation sites of TRADD which were induced by TNF and inhibited by TAK1 inhibitor 5Z7 using mass spectrometry. We found that TAK1 could mediate the phosphorylation of multiple sites in TRADD upon TNF stimulation. We next perf...
ORGANISM(S): Homo Sapiens 
2024-10-05 | PXD056588 |
ProteomicsR406 binding site on TAK1 identified by MS
We identified of R406 and its pro-drug R788 for the treatment of cancer by inducing necroptosis.
ORGANISM(S): Homo Sapiens 
2023-08-28 | PXD044897 |
ProteomicsDiscovery of a cooperative mode of inhibiting RIPK1
We identified a peptide of RIPK1 binding with compound Nec-34
ORGANISM(S): Homo Sapiens 
2021-03-04 | PXD024534 |
MetabolomicsResearch on the quality markers of antioxidant activity of Kai-Xin-San based on spectrum-effect relationship
Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...
2023-12-21 | MTBLS8806 | MetaboLights
MetabolomicsIntegrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis.

This analysis established comprehensive metabolomic profiles of adenomyosis patients and revealed widespread alterations in the metabolome within normal and fibrotic myometrium. Integrated analysis shown significant associations between metabolomic data and fibrosis . This study is the first to d...

2025-05-12 | MTBLS11965 | MetaboLights
ProteomicsMulti-omics reveal the segmentation atlas of hepatocellular carcinoma
We used a comprehensive approach that combined proteome, lipidome, and metabolome data to investigate the segmentation atlas of hepatocellular carcinoma (HCC).
ORGANISM(S): Homo Sapiens 
2024-03-26 | PXD050969 |
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