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ProteomicsPDCD6 modulates LC3-associated phagocytosis-mediated antimicrobial defense by regulating lactate metabolism
LC3-associated phagocytosis (LAP) is critical in host defense against invading pathogens, but the molecular mechanism for LAP activation is still unclear. Here, we find programmed cell death 6 (PDCD6) as a negative regulator of LAP. PDCD6 deficiency in mice and macrophages induces enhanced bacterici...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD056047 | Pride
Lactate Lap Pdcd6 
ProteomicsThe Pharmacological Effect and Mechanism of Lanthanum Hydroxide on Vascular Calcification Caused by Chronic Renal Failure Hyperphosphatemia
Objective: To investigate the treatment and mechanism of lanthanum hydroxide on hyperphosphate-induced vascular calcification in chronic renal failure. Methods: Develop a rat model of CKD hyperphosphatemia. Rats were randomly allocated to the model, lanthanum hydroxide, lanthanum carbonate, Calcium...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD023081 | Pride
Hyperphosphatemia Vascular calcification Lanthanum hydroxide Mechanism Pharmacological effect Chronic renal failure 
TranscriptomicsNOT2 proteins promote Pol II-dependent transcription and interact with multiple miRNA biogenesis factors in Arabidopsis
MicroRNAs (miRNAs) play key regulatory roles in numerous developmental and physiological processes in animals and plants. The elaborate mechanism of miRNA biogenesis involves transcription and multiple processing steps. Here, we report the identification of a pair of evolutionarily conserved NOT2_3_...
ORGANISM(S): Arabidopsis thaliana 
2013-01-30 | E-GEOD-42901 | biostudies-arrayexpress
UnknownC. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program.
Not available
S-EPMC9120479 | biostudies-literature
UnknownTargeting Gsk3a reverses immune evasion to enhance immunotherapy in hepatocellular carcinoma.
Not available
S-EPMC11340705 | biostudies-literature
UnknownA novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release.
Not available
S-EPMC7883739 | biostudies-literature
UnknownAnalyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice.
Not available
S-EPMC5270764 | biostudies-literature
UnknownEpithelial-Mesenchymal Transition Suppresses AMPK and Sensitizes Cancer Cells to Pyroptosis under Energy Stress.
Not available
S-EPMC9322750 | biostudies-literature
UnknownDisruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma.
Not available
S-EPMC10897610 | biostudies-literature
UnknownReplicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.
Not available
S-EPMC5126781 | biostudies-literature
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