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Proteomicsmouse liver kidney LC-MS/MS - Quantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney
Triptolide (TP), the major active component in Tripterygium wilfordii Hook. f. (Tripterygium Glycosides), contributes to treat rheumatoid arthritis and anticancer activities. However, the organ toxicity, especially nephrotoxicity and hepatotoxicity limit its clinical application. To fully understand...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-05 | PXD005434 | Pride
Triptolide  proteomics  kidney  liver  fatty acids  2d-lc-ms/ms  organ toxicity 
ProteomicsIntegrated proteomic and metabolomic profiling the global response of rat glioma model to temozolomide treatment
Temozolomide (TMZ) is the first-line chemotherapeutic drug for glioblastoma treatment. It can induce O6-methylguanine DNA lesions, lead to prolonged G2–M arrest and ultimately cell death. However, the molecular response involved in TMZ inhibiting tumor growth has not been fully elucidated. In this s...
ORGANISM(S): Rattus Norvegicus 
PXD013790 |
ProteomicsUnraveling the mechanism of ethyl acetate extract from Prismatomeris connata Y. Z. Ruan root in treating pulmonary fibrosis: insights from bioinformatics, network pharmacology, and experimental validation
Pulmonary fibrosis (PF) is a terminal lung disease characterized by fibroblast proliferation, accumulation of extracellular matrix accumulation, inflammatory damage, and tissue structure destruction. The pathogenesis of this disease, especiallyparticularly idiopathic pulmonary fibrosis (IPF), is sti...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-07 | PXD048007 | Pride
Inflammation/wound healing balance Macrophages polarization Pulmonary fibrosis Ethyl acetate extract Prismatomeris connata y. z. ruan 
ProteomicsIdentification of zein proteome by multi-enzyme digestion
Zeins are a class of prolamine proteins extracted from maize, and are extensively used in the food and pharmaceutical industries. Therefore, characterization of its components is essential for quality control and safety evaluation. However, zein proteins have low abundance of the trypsin targets lys...
ORGANISM(S): Zea Mays 
2019-07-25 | PXD014743 |
ProteomicsSystematic Proteomics Revealed The mechanism of How Long-term Tibetan Buddhist Meditation Enhanced Cardiovascular Protection
The difficulty to obtain data from whom uninterruptedly practice meditation over many years, and lacking of advanced analysis methods significantly hinder the comprehensive understanding of molecular mechanisms underlying meditation. This study aimed to address this issue.Accordingly, we recruited 8...
ORGANISM(S): Homo Sapiens 
PXD057418 |
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