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TranscriptomicsTracing pluripotency of human early embryos and embryonic stem cells by single cell RNA-seq
Find the casual relationship between gene expression network and cellular phenotype at single cell resolution. We collected donated human pre-implatation embryos, and the embryonic stem cells derived from them, isolate individual cells, prepared single cell cDNAs, and sequenced them by HiSeq2000. Th...
ORGANISM(S): Homo sapiens 
2013-08-10 | E-GEOD-36552 | biostudies-arrayexpress
ProteomicsDysregulation of N-glycosylation by Rpn1 knockout in spermatocytes induces male infertility via endoplasmic reticulum stress in mice
N-glycosylation protein modification plays a crucial regulatory role in numerous biological processes, although their contribution to male reproduction in mammals remains largely undefined. Here, we found that Ribophorin I (RPN1), a subunit of oligosaccharyltransferase complex, is indispensable for ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056290 | Pride
Rpn1  n-glycosylation  meiosis  endoplasmic reticulum stress  fertility 
MetabolomicsMulti-omics Analysis Reveals Multiple Metabolic Processes, Phytohormone Signaling, and the Negative Regulatory Role of ZmPP2CA11 in Maize Seedling Water-Deficit Responses

In this study, the physiological phenotyping, RNA sequencing, widely targeted metabolomics, and phytohormone profiling were used to examine the responses of maize seedlings to progressive PEG-induced osmotic stress and their recovery after PEG removal. 

2026-09-26 | MTBLS15230 | MetaboLights
ProteomicsDysregulation of N-glycosylation by RPN1 knockout in spermatocytes induces male infertility via impaired mitochondrial function in mice
N-glycosylation protein modifications play a crucial regulatory role in numerous biological processes, although their contribution to male reproduction in mammals remains largely undefined. Here, we found that Ribophorin I (RPN1), a subunit of oligosaccharyltransferase complex, is indispensable for ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051379 | Pride
Rpn1  n-glycosylation  meiosis  spermatogenesis  fertility 
ProteomicsOxygen-confined photooxidation represents a novel form of oxidative protein damage
Oxidative modifications can disrupt protein folds and functions, and are strongly associated with human aging and diseases. Conventional oxidation pathways typically involve the free diffusion of reactive oxygen species (ROS), which primarily attack the protein surface. Yet, it remains unclear wheth...
ORGANISM(S): Homo Sapiens (human) Escherichia Coli 
2024-11-27 | PXD056895 | JPOST Repository
ProteomicsEIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis
Translation initiation factor eIF5A facilitates protein synthesis and impacts diverse biological processes, yet its role in transcriptional regulation is poorly understood. Here we find eIF5A highly expressed in diverse spermatogenic cell types. Conditional knockout of Eif5a (SKO) causes complete in...
ORGANISM(S): Mus Musculus 
PXD067244 |
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