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ProteomicsMouse embryonic stem cells LCMS-MS
We hypothesized that uncovering interactions between Pfkp and other proteins could help resolve the mechanism whereby Pfkp regulates germ layer differentiation. Towards this, Pfkp was immunoprecipitated from mESCs and mass spectrometry analysis used to identify a number of potential Pfkp-interacting...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-23 | PXD038944 | Pride
Lcms-ms Mouse Embryonic stem cells 
ProteomicsDifferential proteomic and phosphoproteomic analysis of Hnrnpk conditional knockout mouse testes
In this research, we have used a global analysis of TMT-based quantitative proteome coupled with phosphopeptide-enrichment strategies to reveal the mouse testes proteome and find the PTMs associated with the RNA binding protein hnRNPK using Hnrnpk conditional knockout mouse and WT mouse testes.
ORGANISM(S): Mus Musculus 
2024-09-14 | PXD056125 |
ProteomicsA CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
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