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TranscriptomicsTat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNAs by HIV-1
Herein expression trends of host miRNA were measured in CEMx174 lymphocytes infected with HIV-1NL4-3 or derivative strains deficient in Tat RSS activity (RSS) or vif-/vpr (VV), or unexposed to virus. As expected from previous studies, miRNA trends were different in naive and HIV-1 infected cells. ...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-21892 | biostudies-arrayexpress
ProteomicsRat hippocampal neurons' proteomes
We induced over-expression and under-expression of Camk2b in cultured rat hippocampal neurons through transfection with lentivirus plasmids. Then isobaric tag for relative and absolute quantitation (iTRAQ)-based quantitative proteomics followed by bioinformatics analyses were carried out to explore...
ORGANISM(S): Rattus Norvegicus 
2022-07-27 | PXD033931 |
ProteomicsHippocampal proteomics of CMS-treated rats
We used a chronic mild stress (CMS) protocol to separate susceptible-depression, susceptible-anxiety and insusceptible rat subgroups. Differential proteomes in the hippocampus were analyzed based on isobaric tags for relative and absolute quantitation (iTRAQ) labeling combined with mass spectrometry...
ORGANISM(S): Rattus Norvegicus 
2019-10-21 | PXD015946 |
ProteomicsGlobal effects of RAB3GAP1 dysexpression on the proteome of mouse cortical neurons
The transfection of the in vitro neurons was conducted using the lentivirus for under-expression (partial silencing) or over-expression of RAB3GAP1 to separate UE-RAB3GAP1 (RAB3GAP1 under-expression), UE-Ctrl (over-expression control), OE-RAB3GAP1 (RAB3GAP1 over-expression), and OE-Ctrl (under-expre...
ORGANISM(S): Mus Musculus 
2021-01-04 | PXD023412 |
ProteomicsAnimal proteomics of depression
The amygdala plays a key role in the pathophysiology of depression, but the molecular mechanisms underlying amygdalar hyperactivity in depression remain unclear. In this study, we used a chronic mild stress (CMS) protocol to separate susceptible and insusceptible rat subgroups. Proteomes in the amyg...
ORGANISM(S): Rattus Norvegicus 
2019-01-15 | PXD044124 |
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