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UnknownIn vitro and in vivo analyses on anti-NSCLC activity of apatinib: rediscovery of a new drug target V600E mutation.
Not available
S-EPMC9909954 | biostudies-literature
GenomicsLINE-1 DNA methylation levels in Midnolin KO and Midnolin overexpressing mouse embryonic stem cells
targeted associated bisulfite sequencing (TaBA-seq) on LINE1 elements in Midnolin (Midn) KO ESCs, and wild-type (wt) ESCs harboring a doxycycline-inducible Midnolin transgene in which Midnolin overexpression was induced for 3 days
ORGANISM(S): Mus musculus 
2026-03-01 | E-MTAB-15573 | biostudies-arrayexpress
TranscriptomicsGene expression signatures and pathway analysis of esophageal squamous cell carcinoma
We identified a number of deregulated genes through transcriptome analysis on esophageal squamous cell carcinoma (ESCC) and adjacent normal tissues. Our pathway enrichment analysis suggested that deregulated genes were strongly enriched in multiple functionally linked pathways known to be important ...
ORGANISM(S): Homo sapiens 
2016-07-24 | E-GEOD-77531 | biostudies-arrayexpress
TranscriptomicscDNA microarray data after ATP treatment
A comparative gene expression analysis was performed using cDNA microarray technology in 2B4 and 1E8 cells (subclones derived from PC-3M human prostate carcinoma cell line) to identified the differentially expressed genes between ATP treated and untreated cells Six samples were analyzed. RNA was ext...
ORGANISM(S): Homo sapiens 
2013-03-30 | E-GEOD-45645 | biostudies-arrayexpress
MetabolomicsStudy on the Effect of Bee Venom and Its Main Component melittin In Delaying Skin Aging in Mice
Bee venom (BV) and its main compound melittin (MLT) have antioxidant, anti-inflammatory, and anti-aging activities; however, very little research has been conducted on their effects on skin aging. In this study, a mouse skin aging model induced by D-galactose (D-gal) was constructed via subcutaneous...
2025-05-12 | MTBLS11975 | MetaboLights
ProteomicsMass spectrometry detected proteins interacting with DPP4 in C28/I2 cells
To understand the mechanisms responsible for DPP4 in osteoarthritis, we examined the proteins that interact with DPP4 using IP followed by mass spectrometry.
ORGANISM(S): Homo Sapiens 
PXD054366 |
ProteomicsComprehensive kinomic study via a chemical proteomic approach reveals dynamic kinome reprogramming in hepatocellular carcinoma tissues
To identify kinases of potential therapeutic interest in HCC, a quantitative kinomic study of tumour and adjacent non-tumour liver tissues was performed using a chemical proteomic approach.
ORGANISM(S): Homo Sapiens 
2021-01-26 | PXD023806 |
ProteomicsBioactive components of Mongolian medicinal Gentiana dahurica Fisch. flowers inhibit the NF-κB signaling pathway and ameliorate chronic obstructive pulmonary disease
Bioactive components of Mongolian medicinal Gentiana dahurica Fisch. flowers inhibit the NF-κB signaling pathway and ameliorate chronic obstructive pulmonary disease
ORGANISM(S): Mus Musculus 
PXD076741 |
ProteomicsCopper exposure aggravates motor phenotype via inhibiting mitophagy in SOD1G93A transgenic mice
Background Amyotrophic lateral sclerosis (ALS) is an age-dependent and incurable neurodegenerative disease. It is pathologically characterized by selective degeneration of motor neurons resulting in a catastrophic loss of motor function. Previous studies showed that excess copper (Cu) might have a r...
ORGANISM(S): Mus Musculus 
2023-01-29 | PXD039728 |
ProteomicsMass spectrometry-based protein interactome and phosphoproteomics data upon NRDE2 overexpression
The HEK293T cells transiently expressing Flag-tagged empty vector or Flag-NRDE2-WT were lysed in NETN buffer (10 mM Tris-HCl [pH 8.0], 100 mM NaCl, 1 mM EDTA, and 0.5% NP-40) and immunoprecipitated with anti-Flag M2 agarose (M8823; Sigma-Aldrich, MO, USA). After washing four times with the high stri...
ORGANISM(S): Homo Sapiens 
2024-03-31 | PXD051117 |
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