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Mass spectrometry detected proteins interacting with DPP4 in C28/I2 cells

ABSTRACT: To understand the mechanisms responsible for DPP4 in osteoarthritis, we examined the proteins that interact with DPP4 using IP followed by mass spectrometry.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zeyu Huang

PROVIDER: PXD054366 | iProX | Tue Jul 30 00:00:00 BST 2024

REPOSITORIES: iProX

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Dipeptidyl Peptidase 4 (DPP4) Exacerbates Osteoarthritis Progression in an Enzyme-Independent Manner.

Li Xinyu X Zhang Zhao Z Jiang Wenyu W Ju Yucan Y Guo Weihua W Huang Zeyu Z

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20241216 6

Chondrocyte senescence is a key driver of osteoarthritis (OA). Mitochondrial dysfunction and oxidative stress can induce chondrocyte senescence. However, the specific mechanisms by which senescence contributes to OA progression are not fully understood. Here, it is attested that Dipeptidyl peptidase 4 (DPP4) is significantly upregulated in osteoarthritic chondrocytes in both humans and mice. DPP4 promotes oxidative stress and cellular senescence in chondrocytes through excessive mitochondrial fi ...[more]

PMID: 39680708

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