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TranscriptomicsInhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21 [miRNA expression]
The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit prostate cancer development and/or progression. Studies were performed to determine the effects of a model statin, atorvastatin (ATO), on the proliferation and different...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-46375 | biostudies-arrayexpress
TranscriptomicsInhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21 [Gene expression]
The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit prostate cancer development and/or progression. Studies were performed to determine the effects of a model statin, atorvastatin (ATO), on the proliferation and different...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-46374 | biostudies-arrayexpress
ProteomicsDysferlin deficient mice proteomics
Investigation of age-dependent changes in the proteomic profile of Dysferlin-deficient mouse skeletal muscle relative to healthy muscle.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-01-04 | MSV000088639 | MassIVE
TranscriptomicsMolecular characterization of 4-NQO induced F344 rat tongue carcinogenesis: alteration of multiple gene expression and hypomethylation of PTGS2 proximal promoter
The 4-NQO induced rat tongue carcinogenesis model presenting considerable histologic and molecular similarity to oral cancers commonly seen in humans is very useful for investigating oral carcinogenesis. In order to understand the molecular basis of oral carcinogenesis and identify gene biomarkers ...
ORGANISM(S): Rattus norvegicus 
2014-08-04 | E-GEOD-51125 | biostudies-arrayexpress
ProteomicsAn antibody drug conjugate-like agent DTLL sensitizes gemcitabine-sensitive/resistant pancreatic cancer on basis of SMAD4 profiles
Chemoresistance to gemcitabine limits its clinical implementation for pancreatic ductal adenocarcinoma (PDAC). We previously generated an antibody drug conjugate (ADC) -like agent, EGFR/HER2 dual-targeting ligand-based lidamycin (DTLL), and studied the effect of DTLL combined with gemcitabine and th...
ORGANISM(S): Homo Sapiens 
2022-03-02 | PXD031977 |
ProteomicsSequencing of the mouse testis proteome
The present study analyzed the acute inflammatory response of the testis to viral infection using a proteome approach
ORGANISM(S): Mus Musculus 
PXD045748 |
TranscriptomicsBerry skin development in Norton grape: Distinct patterns of transcriptional regulation and flavonoid biosynthesis
Background: The complex and dynamic changes during grape berry development have been studied in Vitis vinifera, but little is known about these processes in other Vitis species. The grape variety ‘Norton’, with a major portion of its genome derived from Vitis aestivalis, maintains high levels of...
ORGANISM(S): Vitis sp. cv. 'Norton' 
2010-10-08 | E-GEOD-24561 | biostudies-arrayexpress
ProteomicsCitrullinated proteins in platelets and platelets releasing microparticles may serve as a potential target of ACPA
To investigate the expression of peptidylarginine deiminase (PAD) enzymes and mining citrullination proteins in human platelets and platelets releasing microparticles (PRMs), and to determine whether these less-studied platelets associated citrullination proteins can be targeted by anti-citrullinate...
ORGANISM(S): Homo Sapiens 
2022-10-26 | PXD037743 |
ProteomicsMechanistic Insight into Glioma Through Spatially Multidimensional Proteomics
Characterizing the tumor microenvironment at the molecular level is essential for understanding the mechanisms of tumorigenesis and evolution. However, the specificity of the blood proteome in localized region of the tumor and its linkages with other systems is difficult to investigate. Here, we pro...
ORGANISM(S): Homo Sapiens 
PXD043970 |
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