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ProteomicsProteogenomics Connects Somatic Mutations to Signalling in Breast Cancer
Explore This Study at the NCI Proteomic Data Commons

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-08-28 | MSV000084248 | MassIVE
GenomicsWhole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
5-Hydroxymethylcytosine (hmC) is particularly abundant in mammalian brains with yetto be revealed functions. Here, we present genome-wide and single-base-resolutionmaps of hmC and mC in the human brain. We demonstrated that hmCs increasemarkedly from the fetal to the adult stage, and in the adult br...
ORGANISM(S): Homo sapiens 
2014-02-22 | E-GEOD-55249 | biostudies-arrayexpress
Proteomicslabel-free analysis of male-sterile line 1355A of cotton
Cotton (Gossypium spp.) is one of the most important economic crops and exhibits yield-improving heterosis in specific hybrid combinations. The genic male-sterility system is the main strategy used for producing heterosis in cotton. To better understand the mechanisms of male sterility in cotton, we...
ORGANISM(S): Gossypium hirsutum 
2019-03-19 | PXD012398 | Pride
Label-free Gossypium Male sterility 
GenomicsTet and TDG Mediate DNA Demethylation Essential for MET in Somatic Cell Reprogramming
Tet-mediated DNA oxidation is a new type of epigenetic modification in mammals and its role in the regulation of cell fate transition remains poorly understood. Here, we derive mouse embryonic fibroblasts (MEFs) deleted in all three Tet genes and examine their capability to be reprogrammed into iPS ...
ORGANISM(S): Mus musculus 
2014-02-19 | E-GEOD-52741 | biostudies-arrayexpress
GenomicsSingle cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed by reduced representation bisulfite sequencing
We develop a single cell methylome analysis technique based on RRBS, which works robustly for mouse embryonic stem cells (mESCs), sperm, metaphase II oocytes, and zygotes. In total, 36 samples were analyzed, including 8 single mouse embryonic stem cells (mESCs), pooled-5, 10, 20 mESCs, bulk mESCs, 7...
ORGANISM(S): Mus musculus 
2013-08-31 | E-GEOD-47343 | biostudies-arrayexpress
GenomicsActive and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish full developmental potential. Previous studies have suggested that the paternal genome is actively demethylated in the zygote whil...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-56650 | biostudies-arrayexpress
GenomicsActive Demethylation of Both Maternal and Paternal Genomes in Mouse Zygotes
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-methylcytosine (5mC) patterns, are reprogrammed in early embryogenesis to establish full developmental potential. It is broadly accepted that the paternal genome is actively demethylated in the zygote while the materna...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-60777 | biostudies-arrayexpress
ProteomicsMetabolomics in pancreatic cancer cells influenced by MTHFD2
Metabolomics of pancreatic cancer cell are modified by metabolic enzyme MTHFD2. SW1990 cells were transfected with MTHFD2 siRNA and control siRNA. Cells were collected for metabolomics analysis.
ORGANISM(S): Homo Sapiens 
2021-02-18 | PXD024228 |
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