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UnknownIdentification of molecular mechanisms underlying the therapeutic effects of Xintong granule in coronary artery disease by a network pharmacology and molecular docking approach.
Not available
S-EPMC9259182 | biostudies-literature
UnknownPradefovir Treatment in Patients With Chronic Hepatitis B: Week 24 Results From a Multicenter, Double-Blind, Randomized, Noninferiority, Phase 2 Trial.
Not available
S-EPMC9187326 | biostudies-literature
UnknownFirst-In-Human Study on Pharmacokinetics, Safety, and Tolerability of Single and Multiple Escalating Doses of Hepenofovir, a Novel Hepatic Targeting Prodrug of Tenofovir in Healthy Chinese Subjects.
Not available
S-EPMC9161552 | biostudies-literature
MetabolomicsFasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis

Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable. Harmful use of alcohol is one of the greatest risk factors for de...

2023-05-15 | MTBLS5071 | MetaboLights
ProteomicsPotential blood biomarkers for chronic traumatic encephalopathy: the multi-omics landscape of an observational cohort
The present research recruited 4 pairs of gender- and age-matched rmTBI patients with healthy subjects. Their blood samples were collected for exosome isolation, multi-omics screening and low-throughput verification to explore potential diagnostic biomarkers in blood and its exosomes.
ORGANISM(S): Homo Sapiens 
2022-10-21 | PXD037637 |
ProteomicsIcariside II restores vascular smooth muscle cell contractile phenotype by enhancing focal adhesion signaling pathway in rat vascular remodeling model
In this work, we investigated the pharmacological effects of ICS-II on VSMC phenotypic transition and reveal the underlying mechanisms through in vivo and in vitro experiments. Our results highlight the thera-peutic benefits of ICS-II targeting VSMC phenotypic transition and sup-port the potential o...
ORGANISM(S): Rattus Norvegicus 
2022-05-05 | PXD033724 |
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