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Flaviviruses pose growing global health threats and are transmitted by Aedes mosquitoes. Yet, how these viruses overcome early mosquito immunity remains unclear. Here, we reveal a cross-host immune evasion strategy in which the flavivirus NS1 protein, abundantly secreted into infected human serum, i...
ORGANISM(S): Aedes aegypti 
2026-08-18 | PXD067301 | Pride
Bacterial nucleoid-associated proteins play important roles in chromosome organization and global gene regulation. We find that Lsr2 of Mycobacterium tuberculosis is a novel nucleoid-associated protein that specifically binds AT-rich regions of the genome, including regions encoding major virulence ...
ORGANISM(S): Mycobacterium smegmatis 
The integration of proteomics and metabolomics reveals the differences in the uterine tissues of hens producing normal eggs and pimpled eggs
ORGANISM(S): Gallus Gallus 
2024-11-11 | PXD057730 |
The RNA helicase DDX41 is a DEAD-box helicase that is well known as a virus sensor in dendritic cells and a tumor suppressor that is frequently mutated in myeloid neoplasms. However, the functions and relevance of DDX41 in solid tumors remain largely unexplored. In this study, through in vivo CRISPR...
ORGANISM(S): Homo Sapiens 
2024-12-23 | PXD059178 |
we performed longitudinal, unbiased, quantitative proteomics using liver tissues from RES-treated and vehicle-treated DEN/HFD mice
ORGANISM(S): Mus Musculus 
In order to revealed the multiple protein functional modules and kinases networks of human early erythropoiesis. We isolated the CD34+ cells drived from Human umbilical cord blood samples and induced to undergo erythropoiesis in vitro. Then, the cultured erythroid cells were sorted with FACS and sam...
ORGANISM(S): Homo Sapiens 
2022-08-03 | PXD035785 |
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