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ProteomicsCullin 4b modulates Wnt signaling and CRL4b targets Irgm1 to fuel intestinal stem cell stemness and niche
Background & Aims: Hierarchical organization of intestine relies on their stem cells by self-renew and producing committed progenitors. Although signals like Wnt are known to animate the continued renewal by maintaining intestinal stem cells (ISCs) activity, molecular mechanisms especially E3 ubiqui...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD021528 | Pride
Cul4b  intestinal stem cells (iscs)  irgm1  stem cell niche 
MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
OtherThe Tissue-Based Proteogenomics Reveals that Human Testis Endows Plentiful Missing Proteins.
Data from ProteomeXchange, PXD ID: PXD002179. Experiment: CHPP_TESTIS_Tricine, file: CHPP_TESTIS_Tricine_2017.mgf. Published as part of J Proteome Res. 2015 . From the Abstract: {{i}} Investigations of missing proteins (MPs) are being endorsed by many bioanalytical strategies. We proposed that prot...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310023526 | GPMDB
Resource Reanalysis 
ProteomicsHs_C-HPP_Testis_Regular-SDS-PAGE
CN-CHPP 2015 Testis, Regular-SDS-PAGE
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005356 | PeptideAtlas
ProteomicsHs_C-HPP_Testis_Tricine-SDS-PAGE
CN-CHPP 2015 Testis, Tricine-SDS-PAGE
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005333 | PeptideAtlas
ProteomicsCN-CHPP 2015 Testis Project
The testis tissue-based trans-omics was a feasible approach to find more missing proteins (MPs) because it was reported higher gene expression found in testis tissues. Three testis tissues and two protein separation strategies were selected to quantitatively evaluate gene expression abundance at the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-06-26 | MSV000082510 | MassIVE
ProteomicsMi-2β promotes immune evasion in melanoma by activating EZH2 methylation
For identification of Mi-2β-interacting proteins, B16F10 cells (1 × 108) were collected and washed three times with PBS and lysed in lysis buffer on ice for 30 min. Cell lysates were collected and then isolated over night by anti-Mi-2β magnetic agarose beads. The anti-Mi-2β magnetic agarose beads we...
ORGANISM(S): Mus Musculus 
2024-02-18 | PXD049467 |
ProteomicsQuantitative TMT Mass-spec based proteomics on Mycobacterium Abscessus
To study the changes in the TMT proteomics profile of Mycobacterium Abscessus samples, TMT was used as the labeling strategyfor comparative quantitative proteomic analysis.
ORGANISM(S): Mycobacteroides Abscessus Atcc 19977 
2024-05-20 | PXD052419 |
MetabolomicsDeep functional analysis of synII, a 770 kb synthetic yeast chromosome
Here we report the design, construction and characterization of a 770 Kb synthetic yeast chromosome II (synII). With the UPLC-MS method, we demonstrated synII maintains a nearly wild-type phenotype and fitness despite hundreds of designer editing to it. Our phenomics, transcriptomics, proteomics dat...
2016-10-13 | MTBLS296 | MetaboLights
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