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UnknowniASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
Not available
S-EPMC6717262 | biostudies-literature
UnknownPerinatal Care Provider Perspectives on Integrating Clinical Research Into the Clinical Infrastructure.
Not available
S-EPMC11980763 | biostudies-literature
GenomicsNational Cancer Institute (NCI) TARGET: Therapeutically Applicable Research to Generate Effective Treatments

The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative seeks to accelerate research in novel marker and drug development, along with understanding the molecular basis of pediatric malignancy, through identification of genomic changes associated with the follo...

phs000218.v5.p1 | EGA
ProteomicsStructural and functional fine mapping of cysteines in mammalian glutaredoxin reveal a hierarchy of susceptibility to oxidative inactivation
Protein-S-glutathionylation (PSSG) is a post-translational modification involving the conjugation of glutathione to reactive protein thiols, which can modulate the activity and structure of key cellular proteins. Glutaredoxins (GLRX) are oxidoreductases that regulate this process by performing the r...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD026486 | Pride
Molecular dynamics Glutathione Multiscale modeling Redox S-glutathionylation Quantum mechanics 
ProteomicsExtracellular vesicles from osteogenic differentiated human BMSCs
Pathological processes like osteoporosis or steroid-induced osteonecrosis of the hip are accompanied by increased bone marrow adipogenesis. Such disorder of adipogenic/osteogenic differentiation, which affects also bone marrow derived mesenchymal stem cells (BMSCs) contributes to bone loss during ag...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035845 | Pride
Ev Bmsc 
UnknownFood Choice and Dietary Perspectives of Young, Urban, Black Pregnant Women: A Focus Group Study.
Not available
S-EPMC10974382 | biostudies-literature
GenomicsA Case-Controlled Study for Genotype-Phenotype Associations in Multiple Sclerosis (MS)

This is a multi-centre, case-controlled study to develop a dataset containing 1000 MS cases and 1000 matched controls and to associate DNA sequence (allelic) variations with MS phenotypes.

Study subjects were enrolled through a prospective effort initiated in 2003. Three MS clinical ce...

phs000171.v1.p1 | EGA
TranscriptomicsProgrammed fluctuations in sense/anti-sense transcript ratios drive sexual differentiation in Schizosaccharomyces pombe
Strand specific RNA sequencing of S. pombe revealed a highly structured programme of ncRNA expression at over 600 loci. Waves of antisense transcription accompanied sexual differentiation. A substantial proportion of ncRNA arose from mechanisms previously considered to be largely artefactual, includ...
ORGANISM(S): Schizosaccharomyces pombe 
2011-12-20 | E-GEOD-28113 | biostudies-arrayexpress
TranscriptomicsGene expression responses to chronic low dose arsenite exposure
Arsenic (As) exposure is a significant worldwide environmental health concern. Low dose, chronic arsenic exposure has been associated with higher risk of skin, lung, and bladder cancer, as well as cardiovascular disease and diabetes. While arsenic-induced biological changes play a role in disease p...
ORGANISM(S): Homo sapiens 
2015-05-05 | E-GEOD-60760 | biostudies-arrayexpress
TranscriptomicsExpression profile of sweat gland label retaining cells (LRCs)
We have used the slow cycling property, found in hair follicle stem cells, to look for LRCs in sweat glands as putative stem cells. Gene expression profiling allowed us to determine the common and unique genes expressed in SG LRCs and non-LRCs. This allowed us to probe for the signaling pathways act...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-49011 | biostudies-arrayexpress
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