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ProteomicsDe novo designed protein guiding targeted protein degradation
Targeted protein degradation is a powerful tool for biological research, cell therapy, and synthetic biology. However, conventional methods often depend on pre-fused degrons or chemical degraders, limiting their wider applications. In this study, a guided protein labeling and degradation system (GPl...
ORGANISM(S): Escherichia coli 
2025-07-05 | PXD063956 | Pride
Protein degradation  protein design 
UnknownRebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis.
Not available
S-EPMC8255064 | biostudies-literature
UnknownThe disrupted topological properties of structural networks showed recovery in ischemic stroke patients: a longitudinal design study.
Not available
S-EPMC8330082 | biostudies-literature
UnknownSanshen San Formula Hinders Cognitive Function and Pathology in Alzheimer's Disease Through Potentiating the Function of Synapse.
Not available
S-EPMC11979623 | biostudies-literature
UnknownNovel Anthraquinone Compounds Inhibit Colon Cancer Cell Proliferation via the Reactive Oxygen Species/JNK Pathway.
Not available
S-EPMC7180728 | biostudies-literature
UnknownEffect of Vitamin D Supplementation on Glycemic Control in Prediabetes: A Meta-Analysis.
Not available
S-EPMC8707376 | biostudies-literature
Proteomics[HPP-2.0] Integrated and high-throughput approach for sensitive analysis of tyrosine phosphoproteome
In this study, we developed a 96-well microplate-based approach to integrate all the sample preparation steps starting from cell culture to MS-compatible pTyr peptide enrichment in three consecutive 96-well microplates. By assembling engineered SH2 domain onto microplate, non-specific adsorption of ...
ORGANISM(S): Homo Sapiens 
2024-02-03 | PXD049140 |
ProteomicsMulti-omics approaches for liver reveal the antithrombotic mechanism of aspirin eugenol ester in rat thrombosis model
This study aimed to investigate the effect of AEE on the liver of thrombosed rats to reveal its mechanism of thromboprophylaxis. Therefore, a multi-omics approach was used to analyze the liver.
ORGANISM(S): Rattus Rattus 
2024-02-02 | PXD049461 |
ProteomicsSerum Metabolomics in Patients with Ocular Diseases
Serum metabolomics in patients with ocular diseases is a fascinating and emerging field of study. It involves analyzing the metabolites in blood serum to understand the biochemical processes and pathways associated with various eye conditions. This approach provides a deeper insight into the pathoph...
ORGANISM(S): Homo Sapiens 
2024-01-24 | PXD048826 |
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