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UnknownMetformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine.
Not available
S-EPMC11613737 | biostudies-literature
ProteomicsInhalation of ACE2-expressing lung spheroid cell exosomes provides prophylactic protection against SARS-CoV-2
We demonstrated that lung spheroid cell derived exosomes (LSC-Exo) carry the parental cell’s ACE2 that are able to target lung, intercept SARS-CoV-2 entry, confer protection against SARS-CoV-2 infection. This LSC-Exo prophylaxis paradigm would not be limited by viral evolution, showing great potenti...
ORGANISM(S): Homo sapiens (Human) 
2024-01-13 | PXD047542 | Pride
Lc-ms Exosomes 
Unknown[Single nucleotide polymorphism of rs28416520 in Piwil1 gene promoter region is associated with an increased risk of gastric cancer].
Not available
S-EPMC7606242 | biostudies-literature
UnknownSingle-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma.
Not available
S-EPMC9561780 | biostudies-literature
MetabolomicsTowards engineering ectomycorrhization into switchgrass bioenergy crops via a lectin receptor-like kinase
Soil-borne microbes can establish compatible relationships with host plants, providing a large variety of nutritive and protective compounds in exchange for photosynthesized sugars. However, the molecular mechanisms mediating the establishment of these beneficial relationships remain unclear. Our pr...
2021-08-11 | MTBLS2597 | MetaboLights
ProteomicsFBL promotes cancer cell resistance to DNA damage by transcriptionally regulating BRCA1 via YBX1
In order to study the molecular mechanism of FBL in cells, this project constructed the full length of FBL into the SFB (S-Flag-SBP tag) vector, and constructed a stable cell line overexpressing FBL. Affinity chromatography combined with LC-MS/MS technology to screen FBL interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2023-07-26 | PXD034434 | Pride
Human Hct116 cells Nonolc-ms/ms Fbl 
TranscriptomicsOptimized siRNAs with a minimal off-target effect facilitate the screening of essential genes in cancer cells
siRNAs with dN are a promising and easy approach to characterize essential genes by minimizing the off-target effect in cancer cells. mRNA profiles of HCT 116 cells after the transfection of siRNAs or blank control by deep sequencing, using HiSeq 2000
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-62968 | biostudies-arrayexpress
MetabolomicsMulti-kingdom gut microbiota dysbiosis is associated with the development of pulmonary arterial hypertension

Gut microbiota dysbiosis has been implicated in pulmonary arterial hypertension (PAH). However, most studies have focused on the bacterial community and the exact role and mechanisms of multi-kingdom gut microbiota, including bacteria, archaea and fungi in PAH remains largely unclear. Idiopathic ...

2025-05-12 | MTBLS10563 | MetaboLights
ProteomicsTMT Proteomics in Z9 and E9 under Salt Stress
The impact of soil salinity on the growth, development, and yield of upland cotton. To elucidate the molecular mechanism of salt tolerance in upland cotton seedlings, proteomic methods were employed to study the proteomic characteristics of upland cotton leaves at the three-leaf stage after 12 hours...
ORGANISM(S): Gossypium Hirsutum 
2024-12-11 | PXD058796 |
ProteomicsSerine protease HtrA promotes Campylobacter jejuni intestinal colonization through degrading antimicrobial peptide LL-37
We carried out a DNA pull-down assay using the PhtrA promoter as a bait to capture potential direct transcriptional regulators from cellular lysates of P116B strain
ORGANISM(S): Campylobacter Jejuni 
2026-01-31 | PXD073907 |
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