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TranscriptomicsIdentification of promoter sequence elements involved in specific recognition by the ?S subunit of bacterial RNA polymerase.
Promoter recognition by bacterial RNA polymerase is mediated by ? subunits, which assemble transiently to RNA polymerase core enzyme (E) during transcription initiation. ? subunits drive transcription of specific sets of genes by allowing RNA polymerase to interact with different promoter sequences....
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2011-05-31 | E-GEOD-22207 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast cell cycle cdc25 block/release
High-resolution time-course analysis of the fission yeast (S. pombe) cell cycle transcriptional program following synchronization by cdc25 (ts) block and release
ORGANISM(S): Schizosaccharomyces pombe 
2005-03-25 | E-TABM-8 | biostudies-arrayexpress
TranscriptomicsMre11 suppresses replication stress and gene amplification proficiency
Gene amplification, copy-number increases of particular genes and surrounding genomic segments, promotes cancer progression and acquired therapy resistance. Thus, understanding genetic traits that confer gene amplification proficiency is important. The primary step for gene amplification is sponta...
ORGANISM(S): Cricetulus griseus 
2015-03-05 | E-GEOD-59487 | biostudies-arrayexpress
GenomicsGenome-wide analysis of RARβ transcriptional targets in mouse striatum links retinoic acid signaling with Huntington’s disease and other neurodegenerative disorders
The active vitamin A derivative retinoic acid (RA) is an important regulator of adult brain functions. How these regulations are achieved is poorly known, partly due to the paucity of information on RA molecular targets. The striatum, the region involved in control of motor, cognitive and affective ...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-67829 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast cell cycle following synchronization by centrifugal elutriation
High-resolution time-course analysis of the fission yeast (S. pombe) cell cycle transcriptional program following synchronization by centrifugal elutriation
ORGANISM(S): Schizosaccharomyces pombe 
2005-02-16 | E-TABM-5 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of RARβ transcriptional targets in mouse striatum links retinoic acid signaling with Huntington’s disease and other neurodegenerative disorders
Transcriptome analysis of nucleus accumbens shell samples from RARβ-null mutant mice and their wild type littermates The active vitamin A derivative retinoic acid (RA) is an important regulator of adult brain functions. How these regulations are achieved is poorly known, partly due to the paucity ...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-67761 | biostudies-arrayexpress
UnknownPhase I Study Evaluating WEE1 Inhibitor AZD1775 As Monotherapy and in Combination With Gemcitabine, Cisplatin, or Carboplatin in Patients With Advanced Solid Tumors.
Not available
S-EPMC7845944 | biostudies-literature
TranscriptomicsCUT&RUN LoV-U of beta-catenin, TCF/LEF transcription factors and histone modifications in HEK293T and mouse embryonic hindlimb tissue at 11.5 days post coitum
In our attempts to profile different regulators of the WNT/b-catenin transcriptional complex, CUT&RUN failed to produce consistent binding patterns of the non-DNA-binding b-catenin. We developed a modified CUT&RUN protocol, which we refer to as LoV-U (Low Volume and Urea), that enables the generatio...
ORGANISM(S): Mus musculus 
2022-07-16 | E-MTAB-11951 | biostudies-arrayexpress
TranscriptomicsMRCE expression
We have created a global map of the effects of polymorphism on gene expression in 550 children from families recruited through a proband with atopic dermatitis. We genotyped >300,000 SNPs and identified expression quantitative trait loci from measurements of 16,487 probes representing 15,576 genes i...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-MTAB-1428 | biostudies-arrayexpress
ProteomicsProteomic analysis of extracellular vesicles and conditioned medium from human Adipose-derived Stem/Stromal Cells and Dermal Fibroblasts
Conditioned medium (CM) and extracellular vesicles (EV) from human Adipose-derived Stem/stromal cells (ASC) and Dermal fibroblasts (DF) can represent valid cell substitutes in regenerative medicine and other therapeutic applications. Whether one of the two cell products should be preferred over the ...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020219 | Pride
Adipose-derived stromal cells Label-free quantitative proteomics Extracellular vesicles Dermal fibroblasts Conditioned medium Secretome 
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