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This experiment was conducted to identify target genes of the microRNA-499 in skeletal muscle of transgenic mice that overexpressed miR-499. The following abstract from the submitted manuscript describes the major findings of this work. Coupling of mitochondrial function and skeletal muscle f...
ORGANISM(S): Mus musculus 
Unraveling the mechanisms underlying early neural differentiation of ESCs is crucial to the cell-based therapies of neurodegenerate diseases. Neural fate acquisition is proposed to be controlled by a “default” mechanism, for which the molecular regulation is not well understood. In this study, w...
ORGANISM(S): Mus musculus 
Appropriate neural initiation of the pluripotent stem cells in the early embryos is critical for the development of the central nervous system. This process is regulated by the coordination of extrinsic signals and intrinsic programs. However, how the coordination is achieved to ensure proper neural...
ORGANISM(S): Mus musculus 
GPLD1 levels were elevated in HF patients and murine models. Cardiac-specific GPLD1 depletion exacerbated cardiac dysfunction and hypertrophy, while its overexpression ameliorated these effects, dependent on enzymatic activity. uPAR was identified as a potential binding target for GPLD1, and viral-m...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD064470 | Pride
iTRAQ-based quantitative proteomic analysis of heat stress-induced mechanisms in pepper seedlings
ORGANISM(S): Capsicum annuum 
2021-05-06 | PXD019556 | Pride
Lysine crotonylation (Kcr) is a recently-identified protein short-chain acylation. We have previously reported that chromodomain Y-like transcription corepressor CDYL acts as a crotonyl-CoA hydratase and negatively regulates histone Kcr. However, the global crotonylome of CDYL-regulated Kcr on non-h...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD013616 | Pride
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