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ProteomicsCRISPR-Assisted Detection of RNA-Protein Interactions in Living Cells
We develop a CRISPR-Assisted RNA-Protein Interaction Detection method (CARPID), which leverages CRISPR/CasRx-based RNA targeting and proximity labeling to identify binding proteins of specific lncRNA in the native cellular context.
ORGANISM(S): Homo Sapiens 
2020-05-20 | PXD015702 |
ProteomicsDefining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between breast cancer subtypes, and provide clinically relevant biological insights towards TNBC. Using CRISPR/Cas9-mediated gene editing, we identify genes that are specifically regulated by TNB...
ORGANISM(S): Homo Sapiens 
2021-03-04 | PXD024505 |
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