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TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
UnknownStable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.
Not available
S-EPMC7111201 | biostudies-literature
UnknownKv2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3.
Not available
S-EPMC5936832 | biostudies-literature
GenomicsGenome-wide maps of GATA factor occupancy in K562 cells
GATA factors interact with simple DNA motifs (WGATAR) to regulate critical processes, including hematopoiesis, but very few WGATAR motifs are occupied in genomes. Given the rudimentary knowledge of mechanisms underlying this restriction, and how GATA factors establish genetic networks, we used ChIP-...
ORGANISM(S): Homo sapiens 
2009-11-25 | E-GEOD-18868 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD4+ T lymphocytes in response to an irradiation dose of 1 Gy.radiation
Differences in radiosensitivity existing among cells which constitute the lymphocyte population have been known for a long time, although the molecular basis of this differential radiation sensitivity remains unclear. In an attempt to get more insight into the molecular mechanisms leading to radiati...
ORGANISM(S): Homo sapiens 
2005-12-31 | E-MEXP-320 | biostudies-arrayexpress
GenomicsHrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin [MNase-Seq]
We report that the Schizosaccharomyces pombe CHD remodeler, Hrp3, is a global regulator that drives higher-order chromatin structure and genomic stability. The loss of Hrp3 resulted in nucleosome perturbation across the chromosome, and the production of antisense transcripts in the hrp3M-bM-^HM-^F c...
ORGANISM(S): Schizosaccharomyces pombe 
2012-10-02 | E-GEOD-40451 | biostudies-arrayexpress
TranscriptomicsDistinct STAT5 concentrations uniquely control establishment and differentiation of mammary epithelium during pregnancy
To dissect regulatory processes of cell proliferation and differentiation we generated mouse strains carrying any combination of the four Stat5 alleles, thus expressing STAT5 from 0 to 100%. RNA-Seq analyses revealed that different STAT5 levels activate specific genetic programs linked to cell proli...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-37646 | biostudies-arrayexpress
MetabolomicsMetabolomics analyses of cancer tissue from patients with colorectal cancer.
The alteration of metabolism is essential for the initiation and progression of numerous types of cancer, including colorectal cancer (CRC). Metabolomics has been used to study CRC. At present, the reprogramming of the metabolism in CRC remains to be fully elucidated. In the present study, comprehen...
2024-02-08 | MTBLS8090 | MetaboLights
UnknownEffect of temperature on the wetting performance of coal powder by different surfactant solutions: experimental and molecular dynamics simulation study.
Not available
S-EPMC12824158 | biostudies-literature
TranscriptomicsOryza sativa cultivar:Nippobare Transcriptome or Gene expression
We used RNA-Seq to systematically investigate the global transcriptomes of rice which was inoculated with viruliferous SBPH, or inoculated with insect-derived RSV or plant-derived RSV by mechanical inoculation, and generated a useful resource for the immune reaction of rice in face of different kind...
ORGANISM(S): Oryza sativa Japonica Group 
2015-10-18 | E-MTAB-5025 | biostudies-arrayexpress
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