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TranscriptomicsMicroarray skeletal muscle miR-499 overexpressing mice
This experiment was conducted to identify target genes of the microRNA-499 in skeletal muscle of transgenic mice that overexpressed miR-499. The following abstract from the submitted manuscript describes the major findings of this work. Coupling of mitochondrial function and skeletal muscle f...
ORGANISM(S): Mus musculus 
2016-09-03 | E-GEOD-72581 | biostudies-arrayexpress
ProteomicsSalivary Protein Biomarker Detection of Saliva Secretion Disorder in a Primary Sjögren Syndrome Murine Model
Decreased salivary flow is one of the most common symptoms in primary Sjögren syndrome (pSS). The present study was designed to identify a salivary protein biomarker related to saliva secretion disorder in NOD/ShiLtJ mice, a pSS primary murine model. The stimulated saliva was collected from NOD/ShiL...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-21 | PXD008199 | Pride
Biomarker  saliva secretion disorder  sjögren syndrome  saliva  differential proteomic analysis 
TranscriptomicsRNA-seq of Brassica napus seeds at different developmental stages
Understanding the regulation of lipid metabolism is vital for genetic engineering of Brassica napus (B. napus) to increase oil yield or modify oil composition. We report the application of Illumina Hiseq 2000 for transcriptome profiling of seeds of B. napus at different developmental stages, which m...
ORGANISM(S): Brassica napus 
2016-02-06 | E-GEOD-77637 | biostudies-arrayexpress
MetabolomicsComparative metabolomic analysis of exudates of microcystin-producing and microcystin-free Microcystis aeruginosa strains

Cyanobacterial harmful algal blooms (cHABs) dominated by Microcystis aeruginosa threaten the ecological integrity and beneficial uses of lakes globally. In addition to producing hepatotoxic microcystins (MC), M. aeruginosa exudates (MaE) contain various compounds with demonstrat...

2023-01-16 | MTBLS6603 | MetaboLights
MetabolomicsThe telomere-to-telomere (T2T) genome of Peucedanum praeruptorum Dunn provides insights into the genome evolution and coumarin biosynthesis

BACKGROUND: Traditional Chinese medicine has used Peucedanum praeruptorum Dunn (Apiaceae) for a long time. Various coumarins, including the significant root constituents Praeruptorin (A-E), are the active constituents of the dried roots of P. praeruptorum. Previous trans...

2024-04-02 | MTBLS8679 | MetaboLights
ProteomicsOptimization of Protein UFMylation Modification Method and Its Application in Substrate Identification in Human Cells
In this study, we generated the UFSP1KO/UFSP2KO HEK293T cell line and validated it as the most suitable cellular model for the screening, identification, and confirmation of UFMylated substrate proteins. Furthermore, exogenous expression of the E3 ligase components UFL1 and DDRGK1 significantly enha...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD070408 | Pride
Ufsp Ufmylation Ufl1 Ddrgk1 Substrate 
ProteomicsHuman UFSP1 is an active UFM1-specific protease
In order to confirm the translation initiation site of human UFSP1 (UFM1-specific protease 1), we sought to obtain direct evidence using mass spectrometry (MS) for peptide sequencing.
ORGANISM(S): Homo sapiens (Human) 
2022-04-08 | PXD033083 | Pride
Ufmylation  ufm1-specific protease  ufsp1  ufsp2 
Proteomicsto screen the Treg inhibitor and investigate its mechanism in tumor
No Treg-specific therapeutics has been approved for clinical use. Our project aim to screen the Treg inhibitor and investigate its mechanism in tumor.
ORGANISM(S): Homo sapiens (Human) 
2025-01-15 | PXD059236 | Pride
Human ip-ms runx1 
ProteomicsMass Spectrum-based Identification of direct-binding proteins of TAIII-probe
This experiment utilizes a technology platform based on the Ultimate 3000 nano ultra-high-performance liquid chromatography coupled with the Q Exactive Plus high-resolution mass spectrometer, combined with database search software, to perform qualitative (or relative quantitative) analysis of protei...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD060766 | Pride
UnknownDissecting yield-associated loci in super hybrid rice by resequencing recombinant inbred lines and improving parental genome sequences.
Not available
S-EPMC3761582 | biostudies-literature
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