Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...
The aim of our study was to identify gene expression profiles of ductal and lobular carcinomas in relation to normal ductal and lobular cells. We examined ten mastectomy specimens from postmenopausal breast cancer patients. Ductal and lobular tumor and normal cells were microdissected from cryosecti...
Interferon regulatory factor 2 binding protein 2 (Irf2bp2) is a corepressor of Irf2 that suppresses inflammatory gene expression and promotes the M2 macrophage phenotype in bone marrow derived macrophages (BMDM). Loss of Irf2bp2 in male macrophages promotes an inflammatory phenotype. Here, we compar...
We performed proteomics analysis on Lmna-/- hearts from mice at 2 weeks and 1 month of age to investigate the underlying mechanism by which LMNA deletion evokes DCM
