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ProteomicsThe crosstalk between CRL5 and APC/C E3 ligases regulates metastasis and chemo-sensitivity of cancer cells
Cullin-RING ligases (CRLs) and the anaphase-promoting complex/cyclosome (APC/C) are two major multi-subunit ubiquitin ligases essential for protein homeostasis. The underlying mechanism and biological consequence of their crosstalk remain elusive. Here, we employed tandem affinity purification follo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD068961 | Pride
Cul5  apc11  neddylation  metastasis  chemo-sensitivity 
TranscriptomicsExpression mRNA data from human postmortem putamen samples measured using the NanoString nCounter platform
Background: Molecular adaptations in the striatum mediated by dopamine (DA) denervation or Levodopa (L-dopa) treatment have been implicated with the motor deficits found in Parkinson’s disease (PD). Alterations in glutamatergic neurotransmission and anti-oxidant mechanisms are reported to play imp...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77666 | biostudies-arrayexpress
TranscriptomicsExpression miRNA data from human postmortem putamen samples measured using the NanoString nCounter platform
Background: Molecular adaptations in the striatum mediated by dopamine (DA) denervation or Levodopa (L-dopa) treatment have been implicated with the motor deficits found in Parkinsonâ??s disease (PD). Alterations in glutamatergic neurotransmission and anti-oxidant mechanisms are reported to play imp...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77667 | biostudies-arrayexpress
TranscriptomicsLEOPARD Syndrome iPS, BJ iPS and Fibroblasts
Expression data from LEOPARD Syndrome-iPS clones, BJ-iPS cells and parental Fibroblasts 9 samples in total are analyzed. Among 22011 genes in expression data, there are 3657 genes with at least 2 fold expression change between the average of the three fibroblast lines versus all of the iPS lines/HE...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20473 | biostudies-arrayexpress
UnknownThe TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway.
Not available
S-EPMC10244464 | biostudies-literature
TranscriptomicsKRAS-Dependent Sorting of miRNAs and other small RNAs to secreted vesicles
Although long thought to act cell autonomously, mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. We have previously shown that mutant KRAS induces EGFR-ligand trafficking to exosomes and drastically alters exosomal protein contents,...
ORGANISM(S): Homo sapiens 
2015-08-28 | E-GEOD-67004 | biostudies-arrayexpress
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