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TranscriptomicsIdentification of isobutanol response network of E. coli
Isobutanol has emerged as a potential biofuel due to recent metabolic engineering efforts. Here we used gene expression and transcription factor(TF)-gene interaction data, genetic knockouts, and Network Component Analysis (NCA) to map the isobutanol response network of Escherichia coli under aerobic...
ORGANISM(S): Escherichia coli 
2009-10-31 | E-GEOD-13444 | biostudies-arrayexpress
ProteomicsSynthetic Methylotrophic E. coli proteomics
To effectively use methanol derived from CO2 or methane in E. coli, it is crucial to develop a fast-growing strain that can efficiently process methanol. We successfully developed a methylotrophic E. coli strain, SM6, which has a doubling time of 3.5 hours, surpassing the growth rates of typical nat...
ORGANISM(S): Escherichia coli 
2024-04-24 | PXD051688 | Pride
Synthetic methylotroph Methanol Proteomics E. coli Synthetic biology 
GenomicsEscherichia coli
Identification of isobutanol response network of E. coli
PRJNA110041 | ENA
TranscriptomicsEffect of Dietary Supplementation of Selenium (Organic vs. Inorganic) on Liver Gene Expression Profile in Beef Heifers
Selenium (Se) is an essential nutrient for beef cattle health and commercial production. The molecular mechanisms responsible for physiological responses of the animal to dietary Se supplementation, however, have not been evaluated. Furthermore, the potential effect of two chemical forms (organic vs...
ORGANISM(S): Bos taurus 
2010-04-28 | E-GEOD-19696 | biostudies-arrayexpress
TranscriptomicsPolycomb Repressor Complex2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype
These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results show that H3K27me3-enriched genes show no de-repression in REST-/- ESCs, while REST target genes show significant de-repression. RNA-seq was ...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-59442 | biostudies-arrayexpress
GenomicsPolycomb Repressor Complex 2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype.
These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results showed that a majority of REST-bound genomic regions were not associated with H3K27me3 enrichment and loss of H3K27me3 enrichment was not a g...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-48320 | biostudies-arrayexpress
UnknownTBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss.
Not available
S-EPMC7058506 | biostudies-literature
UnknownIntravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
Not available
S-EPMC10600726 | biostudies-literature
TranscriptomicsSystematic meta-analysis and replication of genome-wide expression studies of Parkinson’s disease: 4
Analysis of substantia nigra from postmortem brains of 4 patients with Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra. Fresh frozen tissue blocks from cerebellar hemispheres of PD patients and controls were provided by the Queens S...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-GEOD-20314 | biostudies-arrayexpress
TranscriptomicsSystematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson’s disease
Analysis of human dopamine (DA) from postmortem brains of 8 patients with Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra. Human dopamine (DA) neurons from 8 PD and 9 control subjects were obtained. Double-stranded complementary DNA...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-GEOD-24378 | biostudies-arrayexpress
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