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ProteomicsData-Independent Acquisition Mass Spectrometry Identification of Serum-derived Extracellular Vesicle Proteomics for Gastric Adenocarcinoma
Timely diagnosis of gastric adenocarcinoma (GAC) can effectively prevent the deterioration of the disease and significantly improve the survival rate of patients. Currently, tumor markers used in clinical practice cannot meet the needs of patients, and it is urgent to develop biomarkers with high se...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD027535 | Pride
Proteomics Extracellular vesicles Serum Gastric adenocarcinoma 
ProteomicsIntegrated proteome and phosphoproteome analysis of gastric adenocarcinoma reveals molecular signatures capable of stratifying patient outcome
Lymph node metastasis is one of the main causes for the low survival rate of gastric cancer patients. Exploring key proteins players in the progression of gastric adenocarcinoma (GAC) may provide new prognostic parkers and therapeutic strategies. we applied proteomic analysis to compare tumor tissue...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD033622 | Pride
Tnxb  spon1  biomarker  lymph node metastasis  gastric adenocarcinoma 
Proteomics,Multiomicsembryo_proteome
We collected over 8000 mouse embryos of each developmental stage (zygote, 2-cell, 4-cell, 8-cell, morula, blastocyst) and performed tandem mass tag (TMT)-based quantitative mass spectrometry and identified nearly 5000 proteins for each stage. In-depth analysis indicates that protein expression profi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-12-10 | MSV000079417 | MassIVE
ProteomicsA proteomic classifier panel for early screening of colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer-related death. Diagnosis at an early stage can greatly improve the patient outcome. Therefore, developing sensitive and specific non-invasive screening and diagnostic methods has a tremendous potential to combat the disease.
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042639 | Pride
Plasma proteome biomarker 
ProteomicsA proteomic classifier panel for early screening of colorectal cancer part II
Colorectal cancer (CRC) is a leading cause of cancer-related death. Diagnosis at an early stage can greatly improve the patient outcome. Therefore, developing sensitive and specific non-invasive screening and diagnostic methods has a tremendous potential to combat the disease.
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042652 | Pride
Plasma proteome biomarker 
ProteomicsProteomic analysis of primary tumor and lymph metastatic tissues as well as lung cancer cells
4 pairs of matched primary versus metastatic tumor tissues from formalin-fixed, paraffin-embedded (FFPE) tissue bank,and two frozen lung tumor tissues from patients with primary orlymph metastasis. Then performed tandem mass tag (TMT) labeling and quantitative mass spectrometry analysis. A549 Cells ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025052 | Pride
Human Tmt Lung A549 Lymph Lc-ms/ms 
ProteomicsProteome and phosphoproteome analysis of monkey brains with PINK1 depletion
PINK1 protein is highly expressed in primate brains. CRISPR-Cas9-mediated depletion of PINK1in fetal and adult monkey brains causes severe neurodegeneration without affecting mitochondrial proteins and morphology.
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2022-02-16 | PXD023520 | Pride
Pink1 monkey proteome phosphoproteome 
ProteomicsLarge-scale identification of lysine crotonylation
Lysine crotonylation on histones is a recently identified post-translational modification that has been demonstrated to associate with active promoters and to directly stimulate transcription.Given that crotonyl-CoA is essential for the acyl transfer reaction and it is a metabolic intermediate widel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-06-11 | MSV000079810 | MassIVE
ProteomicsAnalysis of phosphoproteome reveals PINK1 regulation of BAD function and cell death
We interrogated whether there existed a broader effect of PINK1-dependent phosphorylation after mitochondrial damage by utilizing primary cultured neurons from WT and Pink1 KO mice. Because persistent depolarization leads to mitochondrial damage, we treated cultured neurons with the protonophore car...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-04-08 | MSV000080893 | MassIVE
ProteomicsAnalysis of neuronal phosphoproteome reveals PINK1 regulation of BAD function and cell death
We interrogated whether there existed a broader effect of PINK1-dependent phosphorylation after mitochondrial damage by utilizing primary cultured neurons from WT and Pink1 KO mice. Because persistent depolarization leads to mitochondrial damage {}, we treated cultured neurons with the protonophore ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-04-14 | MSV000080923 | MassIVE
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