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GenomicsGene and protein sequence features augment HLA class I ligand predictions (mRNA sequencing)
Gene and protein sequence features augment HLA class I ligand predictions (mRNA sequencing)
PRJNA868577 | ENA
GenomicsGene and protein sequence features augment HLA class I ligand predictions (ribosome profiling)
Gene and protein sequence features augment HLA class I ligand predictions (ribosome profiling)
PRJNA868576 | ENA
GenomicsGene and protein sequence features augment HLA class I ligand predictions.
Gene and protein sequence features augment HLA class I ligand predictions.
PRJNA868572 | ENA
TranscriptomicsGene and protein sequence features augment HLA class I ligand predictions (mRNA sequencing)
The sensitivity of malignant tissues to T cell-based cancer immunotherapies is dependent on the presence of targetable HLA class I ligands on the tumor cell surface. Peptide intrinsic factors, such as HLA class I affinity, likelihood of proteasomal processing, and transport into the ER lumen have al...
ORGANISM(S): Homo sapiens 
2023-01-08 | GSE210999 | GEO
OtherGene and protein sequence features augment HLA class I ligand predictions (ribosome profiling)
The sensitivity of malignant tissues to T cell-based cancer immunotherapies is dependent on the presence of targetable HLA class I ligands on the tumor cell surface. Peptide intrinsic factors, such as HLA class I affinity, likelihood of proteasomal processing, and transport into the ER lumen have al...
ORGANISM(S): Homo sapiens 
2023-01-08 | GSE210998 | GEO
ProteomicsLigand-induced shifts in conformational ensembles that predict transcriptional activation
Nuclear receptors function as ligand-regulated transcription factors whose ability to regulate diverse physiological processes is closely linked with conformational changes induced upon ligand binding. Understanding how conformational populations of nuclear receptors are shifted by various ligands c...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD036076 | Pride
Lc-msms 
UnknownTemperature artifacts in protein structures bias ligand-binding predictions.
Not available
S-EPMC8447925 | biostudies-literature
UnknownAssessment of ligand-binding residue predictions in CASP9.
Not available
S-EPMC5628505 | biostudies-literature
ProteomicsDeep motif deconvolution of HLA-II peptidomes
CD4 T cells are key for priming and regulating immune recognition of infected and cancer cells, but predictions of class II epitopes have limited accuracy. We profiled over 100’000 HLA-II ligands by Mass Spectrometry and developed a novel motif deconvolution algorithm to analyze these data. Our work...
ORGANISM(S): Homo sapiens (Human) 
2019-10-16 | PXD012308 | Pride
Immunopeptidomics Ligand predictions Mass spectrometry Hla class ii Neoantigens 
UnknownAssessment of Pharmaceutical Protein-Ligand Pose and Affinity Predictions in CASP16.
Not available
S-EPMC12750038 | biostudies-literature
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