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TranscriptomicsGenome-wide analysis of gene expression in MLL translocation transformed mouse leukemia cell lines
The purpose of this study is to investigate the transcriptional programs as it relates to disease latency initiated by different MLL fusion proteins, including: MLL-AF1p, MLL-AF6, MLL-Gas7, MLL-AF9 and MLL-ENL. Leukemia cell lines were established by transforming kit+ mouse bone marrow cells with re...
ORGANISM(S): Mus musculus 
2016-07-07 | E-GEOD-73457 | biostudies-arrayexpress
UnknownIL-33 promotes double negative T cell survival via the NF-κB pathway.
Not available
S-EPMC10076344 | biostudies-literature
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
ProteomicsHuman T21 Amniocyte samples LC-MS/MS
Amniocyte samples of T21 males, T21 females, CN males, and CN females were collected by amniocentesis. The quantitative value of the peptide corresponding to each sample was determined through quantitative analysis by mass spectrometry.
ORGANISM(S): Homo Sapiens 
2022-03-31 | PXD032883 |
MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
MetabolomicsEffects of Trichoderma and Salicylic Acid/Methyl Jasmonate on the Growth, Development, and Lipid Metabolism of Codonopsis pilosula

Endophytic fungi and phytohormone signaling can jointly influence growth–defense trade-offs in medicinal plants by reprogramming metabolism in a stage-dependent manner. To elucidate how the endophytic fungus Trichoderma longibrachiatum FG and exogenous salicylic acid (SA) and methyl jasmonat...

2026-03-24 | MTBLS14124 | MetaboLights
ProteomicsAn ITRAQ-Based Quantitative Proteomics Analysis of the Hepatoprotective Effect of Melatonin on ANIT-Induced Cholestasis in Rats.
The aim of the present study was to investigate the therapeutic mechanism of the anti-cholestatic effects of melatonin against ANIT-induced liver injury in rats, and to screen for potential biomarkers of cholestasis through isobaric tags for relative and absolute quantitation (iTRAQ) quantitative pr...
ORGANISM(S): Rattus Norvegicus 
2020-12-16 | PXD023155 |
ProteomicsProtein mass spectrum analysis of gastrocnemius from CKD and NC mice
As for gastrocnemius (CKD vs. NC =4 vs. 4), the protein was extracted by homogenate and SDT lysis. Next, we did the following steps: SDS-PAGE separation, Filter-aided sample preparation (FASP Digestion), TMT labeling, peptide fractionation with reversed-phase (RP) chromatography and mass spectrometr...
ORGANISM(S): Mus Musculus 
2024-08-25 | PXD055326 |
ProteomicsProtein mass spectrum analysis of serum from CKD and NC mice
As for serum (CKD vs. NC =4 vs. 4), the protein was extracted by homogenate and SDT lysis. We utilized immunoaffinity depletion of serum high-abundance proteins. Next, we did the following steps: SDS-PAGE separation, Filter-aided sample preparation (FASP Digestion), TMT labeling, peptide fractionati...
ORGANISM(S): Mus Musculus 
2024-08-25 | PXD055324 |
UnknownRADX protects against intestinal inflammation by restraining IFI16-mediated innate immunity
Not available
S-SCDT-10_1038-S44321-026-00494-6 | biostudies-other
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