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TranscriptomicsIsl1-Lhx3 fusion specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs
Combinatorial transcription codes generate the myriad of cell types during development, and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM-complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in e...
ORGANISM(S): Mus musculus 
2012-02-03 | E-GEOD-35510 | biostudies-arrayexpress
TranscriptomicsGene expression regulation by C. elegans SAM-10
Little is known about transcriptional control of neurite branching or presynaptic differentiation, events that occur relatively late in neuronal development. Using the C. elegans mechanosensory circuit as an in vivo model, we show that SAM-10, an ortholog of mammalian Single-Stranded DNA binding P...
ORGANISM(S): Caenorhabditis elegans 
2010-11-12 | E-GEOD-25285 | biostudies-arrayexpress
TranscriptomicsSenescent and myofibroblastic cancer-associated fibroblasts share a contractile phenotype regulated by NOX4 generation of reactive oxygen species in the tumour microenvironment
Cancer associated fibroblasts characterized by an myofibroblastic phenotype play a major role in the tumour microenvironment, being associated with poor prognosis. We found that this cell population is made in part by senescent fibroblasts in vivo. As senescent fibroblasts and myofibroblasts have be...
ORGANISM(S): Homo sapiens 
2017-06-01 | E-MTAB-3101 | biostudies-arrayexpress
GenomicsHistone Methylation Regulates Nephron Progenitor Cell Fate in Mice
We report the use of high-throughput sequencing of histone methylation ChIP to compare the H3K4me3 and H3K27me3 methylation states in sequential mouse nephron progenitor lineages Examination of 2 different histone modifications in 2 cell types.
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-40742 | biostudies-arrayexpress
UnknownHierarchical Self-Assembly of Thickness-Modulated Block Copolymer Thin Films for Controlling Nanodomain Orientations inside Bare Silicon Trenches.
Not available
S-EPMC7918743 | biostudies-literature
UnknownClinical symptoms, comorbidities and health outcomes among outpatients infected with the common cold coronaviruses versus influenza virus.
Not available
S-EPMC11462790 | biostudies-literature
GenomicsWhole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information. Integrative clus...
EGAS00001001653 | EGA
TranscriptomicsDe Novo Assembly and Characterization of Stress Transcriptome in a salinity-Tolerant Variety CS52 of Brassica juncea
Oilseed mustard, Brassica juncea, exhibits high levels of genetic variability for salinity tolerance. To obtain the global view of transcriptome and investigate the molecular basis of salinity tolerance in a salt-tolerant variety CS52 of B. juncea, we performed transcriptome sequencing of control an...
ORGANISM(S): Brassica juncea 
2015-02-28 | E-GEOD-66389 | biostudies-arrayexpress
UnknownImplementation outcomes of a patient decision-aid in a diverse population with systemic lupus erythematosus in 15 US rheumatology clinics.
Not available
S-EPMC12316375 | biostudies-literature
UnknownThe global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12687902 | biostudies-literature
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