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TranscriptomicsTranscription profiling of C. elegans pocket protein ortholog, lin-35
LIN-35 is the single C. elegans ortholog of the mammalian pocket protein family members, pRb, p107, and p130. To gain insight into the roles of pocket proteins during development, a microarray analysis was performed with lin-35 mutants. Stage-specific regulation patterns were revealed, indicating th...
ORGANISM(S): Caenorhabditis elegans 
2008-06-14 | E-GEOD-6547 | biostudies-arrayexpress
ProteomicsA conserved chronobiological complex times C. elegans development; map LIN-42 interacting proteins
The mammalian PAS-domain protein PERIOD (PER) and its C. elegans orthologue LIN-42 have been proposed to constitute an evolutionary link between two distinct, circadian and developmental, timing systems. However, while the function of PER in animal circadian rhythms is well understood molecularly an...
ORGANISM(S): Caenorhabditis elegans 
2025-10-10 | PXD058601 | Pride
Kin-20 Lin-42 Ck1bd Phosphorylation Pas-domain protein period C. elegans development 
TranscriptomicsExpression data from small intestinal Lin-c-Kit+Sca-1- cells and Lin-c-Kit-Sca-1- cells.
Small intestinal innate lymphoid cells (ILCs) are known to regulate intestinal epithelial cell homeostasis and to help prevent pathogenic bacterial infections, by producing IL-22. However, other functions of these cells and the lineal relationship between ILCs and lymphoid or myeloid cells have not ...
ORGANISM(S): Mus musculus 
2012-09-15 | E-GEOD-40882 | biostudies-arrayexpress
ProteomicsA conserved chronobiological complex times C. elegans development; map in vivo LIN-42 phosphorylation sites
The mammalian PAS-domain protein PERIOD (PER) and its C. elegans orthologue LIN-42 have been proposed to constitute an evolutionary link between two distinct, circadian and developmental, timing systems. However, while the function of PER in animal circadian rhythms is well understood molecularly an...
ORGANISM(S): Caenorhabditis elegans 
2025-10-10 | PXD058598 | Pride
Kin-20 Lin-42 Ck1bd Phosphorylation Pas-domain protein period C. elegans development 
MetabolomicsFunctional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming
The axolotl (Ambystoma mexicanum) is a caudate amphibian, which has an extraordinary ability to restore a wide variety of damaged structures by a process denominated epimorphosis. While the origin and potentiality of progenitor cells that take part during epimorphic regeneration are known to ...
2021-11-04 | MTBLS1708 | MetaboLights
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
TranscriptomicsTranscription profiling of human 493-6 cells (human EBV-transformed B lymphocytes) were infected with a retrovirus that produces human Lin-28B or empty virus to identify Myc- and Lin-28B-responsive transcripts
In order to examine the consequences of Myc and Lin-28B induction on the transcriptome, P493-6 cells (human EBV-transformed B lymphocytes) were infected with a retrovirus that produces human Lin-28B or empty virus as a control. Gene expression profiles were then monitored in the high and low Myc sta...
ORGANISM(S): Homo sapiens 
2009-03-14 | E-GEOD-14302 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans lin-14 mutants
A temporal gradient of the novel nuclear protein LIN-14 specifies the timing and sequence of stage-specific developmental events in Caenorhabditis elegans. The profound effects of lin-14 mutations on worm development suggest that LIN-14 directly or indirectly regulates stage-specific gene expression...
ORGANISM(S): Caenorhabditis elegans 
2007-01-05 | E-SMDB-3919 | biostudies-arrayexpress
TranscriptomicsMx-Cre mediated deletion of SRF in murine hematopoietic LSK (Lin-Sca1+c-Kit+) cells
Analysis of hematopoietic LSK(Lin-Sca1+c-Kit+) cells lacking the Serum response factor (SRF) gene. Results provide insight into the role of SRF in regulating genetic programs important for hematopoietic stem cell development Comparison of the gene expression profile between murine Lin-Sca1+c-Kit+ ce...
ORGANISM(S): Mus musculus 
2010-08-12 | E-GEOD-23556 | biostudies-arrayexpress
TranscriptomicsGene expression data of Lsd1fl/fl and Lsd1fl/fl Mx1Cre CD150+ CD48- lin- c-Kit+ Sca-1+ LT-HSCs
We discovered that mice that lack Lsd1 in hematopoietic cells were exhibited increased frequencies of CD150+ CD48- lin- c-Kit+ Sca-1+ LT-HSCs, but completely lacked the lin- c-Kit+ Sca-1- myeloid progenitor compartment. To determine the genes altered by Lsd1-loss, CD150+ CD48- lin- c-Kit+ Sca-1+ LT-...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-40284 | biostudies-arrayexpress
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