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TranscriptomicsSensory ray genes
These experiments were undertaken with the goal of identifying genes whose expression is enriched in or restricted to the sensory rays of the C. elegans male tail. We constructed two mutant strains in which ray development is either compromised (EM672) or enhanced (EM673), and harvested mRNA from ad...
ORGANISM(S): Caenorhabditis elegans 
2006-01-05 | E-GEOD-3979 | biostudies-arrayexpress
TranscriptomicsshRNA mediated knockdown of TRA2B and SRSF3 in HEK293 cell line
We have independently knocked down TRA2B and SRSF3 in HEK293 cells to identify the sum of alternative splicing changes that results from depletion of each factor. Each was compared to a control transfection of the hairpin vector alone. In this set, 9 total samples were analyzed. There were three b...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-36069 | biostudies-arrayexpress
TranscriptomicsDigitoxin treatment versus control in HEK293 cells
We treated HEK293 cells with the cardiotonic steroid digitoxin to identify alternative splicing changes as compared to DMSO treatment alone. In this set, 6 total samples were analyzed. There were three biological replicates for each of two conditions: DMSO treatment and Digitoxin treatment. Arrays...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-36058 | biostudies-arrayexpress
TranscriptomicsCis-regulatory architecture of a brain-signaling center predates the origin of chordates
Genomic approaches have predicted hundreds of thousands of tissue specific cis-regulatory sequences, but the determinants critical to their function and evolutionary history are mostly unknown1-4. Here, we systematically decode a set of brain enhancers active in the zona limitans intrathalamica (zli...
ORGANISM(S): Mus musculus 
2016-03-25 | E-GEOD-78005 | biostudies-arrayexpress
TranscriptomicsGene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame-retardants.
The use of chemical flame-retardants (FR) in consumer products has steadily increased over the last 30 years. Toxicity data exist for legacy FRs such as pentabromodiphenyl ether (pentaBDE), but less is known about effects of new formulations. To address this issue, the toxicity of seven FR chemicals...
ORGANISM(S): Daphnia magna 
2015-11-06 | E-GEOD-74736 | biostudies-arrayexpress
GenomicsNitric oxide regulates gene expression in cancers by controlling histone posttranslational modifications [HiSeq 2000]
Dynamic changes in histone posttranslational modifications (PTMs) are important regulators of chromatin structure and gene transcription in both normal and disease settings. Herein, we describe a novel signaling mechanism of nitric oxide (•NO) by demonstrating its ability to modulate gene expressi...
ORGANISM(S): Homo sapiens 
2015-11-05 | E-GEOD-66318 | biostudies-arrayexpress
TranscriptomicsNitric oxide regulates gene expression in cancers by controlling histone posttranslational modifications [PrimeView]
Dynamic changes in histone posttranslational modifications (PTMs) are important regulators of chromatin structure and gene transcription in both normal and disease settings. Herein, we describe a novel signaling mechanism of nitric oxide (â?¢NO) by demonstrating its ability to modulate gene expressi...
ORGANISM(S): Homo sapiens 
2015-11-05 | E-GEOD-66322 | biostudies-arrayexpress
UnknownGenome-wide association study identifies susceptibility loci for acute myeloid leukemia.
Not available
S-EPMC8556284 | biostudies-literature
TranscriptomicsFine-Scale Mapping and Sequencing of Structural Variation from Eight Human Genomes
Genetic variation amongst individual humans occurs on many different scales, ranging from gross alterations in the human karyotype to single-nucleotide changes. In this manuscript we explore variation on an intermediate scale-particularly insertions, deletions, and inversions affecting from a few t...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-10008 | biostudies-arrayexpress
UnknownBlood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study.
Not available
S-EPMC8260104 | biostudies-literature
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