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ProteomicsMouse bone marrow fibrosis LC-MS/MS
Bone marrow fibrosis (BMF) disrupts normal blood cell production, and excessive activation of the TGF-β signaling pathway is considered a key factor in the progression of the disease. Therefore, regulating TGF-β secretion is crucial for reversing fibrotic conditions. Histone deacetylase inhibitors (...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD055276 | Pride
Mouse Bone marrow fibrosis Lc-ms/ms 
ProteomicsNucleus-Translocated GCLM Promotes Chemoresistance in Colorectal Cancer through a Moonlighting Function
Emerging evidence indicates that metabolic enzymes perform moonlighting functions during tumor progression, including the modulation of chemoresistance. However, the underlying mechanisms of these functions remain elusive. In this study, utilizing a metabolic CRISPR-Cas9 knockout library screen, we ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-15 | PXD055376 | Pride
Nuclear gclm  moonlighting function  nkrf  phosphorylation  chemoresistance lc-ms/ms 
Proteomicsspint1 specific knokout in mouse pancreas islet SILAC
SPINT1 is a membrane-anchored serine protease inhibitor that modulates pericellular proteolysis. The pancreas-specific disruption of Spint1 in mice significantly decreased islet size and mass, leading to glucose intolerance, which was causally related to the down-regulation of MafA and insulin. Mech...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-01 | PXD039190 | Pride
Spint1 Silac Islet Mouse 
UnknownHigh-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition.
Not available
S-EPMC12317122 | biostudies-literature
UnknownThe Peripheral Blood Mononuclear Cell Count Is Associated With Bone Health in Elderly Men: A Cross-Sectional Population-Based Study.
Not available
S-EPMC4839837 | biostudies-literature
UnknownRecombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease.
Not available
S-EPMC4391779 | biostudies-literature
UnknownCo-expression of Dorsal and Rel2 Negatively Regulates Antimicrobial Peptide Expression in the Tobacco Hornworm Manduca sexta.
Not available
S-EPMC4742911 | biostudies-literature
UnknownExtracorporeal Membrane Oxygenation in Immunocompromised Patients With Acute Respiratory Distress Syndrome-A Retrospective Cohort Study.
Not available
S-EPMC8679966 | biostudies-literature
Unknownc-Myc Acts as a Competing Endogenous RNA to Sponge miR-34a, in the Upregulation of CD44, in Urothelial Carcinoma.
Not available
S-EPMC6826510 | biostudies-literature
UnknownA computational analysis of the oncogenic and anti-tumor immunity role of P4HA3 in human cancers.
Not available
S-EPMC11573185 | biostudies-literature
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