Sort   by:  
 Page size 
MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
ProteomicsComparison of the ability of exosomes and ectosomes derived from mesenchymal stem cells to promote cartilage regeneration in a rat osteochondral defect model
Background: Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) offer promising prospects for stimulating cartilage regeneration. The different formation mechanisms suggest that exosomes and ectosomes possess different biological functions. However, little attention has been paid...
ORGANISM(S): Rattus Rattus 
PXD041283 |
ProteomicsNanoliposuction recycles senescent cell lipids for lubrication
This study aims to systematically profile membrane protein alterations associated with chondrocyte senescence, in order to identify surface markers specifically upregulated in aged cartilage. We established two in vitro models by treating primary chondrocytes with IL-1β or bleomycin, and one in vivo...
ORGANISM(S): Mus Musculus 
PXD064867 |
ProteomicsBRD4 regulates the osteogenic differentiation of MSCs
MSCs were lysed in cell lysis buffer for Western blotting and IP (Beyotime, Cat. No. P0013). A Dynabeads™ protein G immunoprecipitation kit (Invitrogen, Cat. No. 10007D) was used for Co-IP according to the manufacturer’s instructions. Dynabeads were resuspended and placed on a magnet to remove the s...
ORGANISM(S): Homo Sapiens 
PXD034615 |
ProteomicsDecoding the Femoral and Tibial Entheses of the Human Anterior Cruciate Ligament
To analyze the location-specific graduated mineral composition and assembly, and mechanical transitions of the FE and TE in human knee joints.
ORGANISM(S): Homo Sapiens 
PXD056631 |
Sort   by:  
 Page size