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TranscriptomicsTCF7 is a key regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line
A critical problem in biology is understanding how cells choose between self-renewal and differentiation. To generate a comprehensive view of the mechanisms controlling early hematopoietic precursor self-renewal and differentiation, we used systems-based approaches and murine EML multipotential hema...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-30068 | biostudies-arrayexpress
TranscriptomicsG-CSF mobilizes CD34+ regulatory monocytes that inhibit Graft-versus-Host Disease
Administration of G-CSF mobilizes a unique population of CD11b+Ly6C+CD34+mature monocytes that can inhibit GVHD in murine models of BMT via an iNOS-dependent mechanism. The transcriptional profiles of flow sorted lineage-CD11b+CD34+ cells from G-CSF treated mice were compared with conventional sple...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-65670 | biostudies-arrayexpress
GenomicsTCF7 is a key regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line
A critical problem in biology is understanding how cells choose between self-renewal and differentiation. To generate a comprehensive view of the mechanisms controlling early hematopoietic precursor self-renewal and differentiation, we used systems-based approaches and murine EML multipotential hema...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-31221 | biostudies-arrayexpress
TranscriptomicsGene expression comparisons of megakaryocyte-erythrocyte progenitors isolated from wild type and c-MybTG/c-MybTG mice
Transgene insertion in proximity to the c-Myb gene disrupts c-Myb expression in megakaryocyte-erythrocyte progenitors (MEPs), resulting in skewed commitment to megakaryocyte lineage. To understand the genes regulated by c-Myb at the megakaryocyte-erythrocyte bifurcation, MEPs of c-MybTG/c-MybTG mic...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-19901 | biostudies-arrayexpress
UnknownA TRPV4 mutation caused Charcot-Marie-Tooth disease type 2C with scapuloperoneal muscular atrophy overlap syndrome and scapuloperoneal spinal muscular atrophy in one family: a case report and literature review.
Not available
S-EPMC10311707 | biostudies-literature
TranscriptomicsTet2-/-Flt3ITD and WT stem and progenitor cells
The study was a comparison of gene expression using RNA-seq. We analyzed the stem and progenitor cells from WT and Vav-cre+ Tet2fl/fl Flt3-ITD (T2F3) mice. We isolated stem cells LSK (lin- sca+ kit+) and granulocyte-macrophage progenitors GMP (lin- sca- kit+ fcgr+ cd34+) cells from bone marrow. Comp...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-57244 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization to map an amplified region in 1q23 in human sarcomas
Mapping of an amplified region in 1q23 in sarcomas using array CGH.
ORGANISM(S): Homo sapiens 
2005-11-01 | E-MEXP-427 | biostudies-arrayexpress
TranscriptomicsGenistein Protects Hematopoietic Stem Cells against G-CSF-Induced DNA Damage
Granulocyte colony-stimulating factor (G-CSF) has been utilized to treat neutropenia in various clinical settings. Although clearly beneficial, there are concerns that use of G-CSF in certain conditions increases the risk of myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML). The mos...
ORGANISM(S): Mus musculus 
2014-02-07 | E-GEOD-54737 | biostudies-arrayexpress
TranscriptomicsGenes affected by Satb1 deficiency in HSC, LMPP and CLP
To understand gene expression signatures between wild-type and Satb1-deficient cells To examine genes regulated by Satb1 expression, sets of microarrays were conducted with Lin- c-kitHi Sca-1+ Flt3- HSC-enriched cells, Lin- c-kitHi Sca-1+ Flt3+LMPP-enriched cells, and Lin- c-kitLo Sca-1Lo IL7Rα+ C...
ORGANISM(S): Mus musculus 
2013-03-20 | E-GEOD-45299 | biostudies-arrayexpress
TranscriptomicsGenes affected by SFRP5 overexpression in LSK cells and CLP
To understand gene expression signatures between wild-type and SFRP5-overexpressing cells To examine genes regulated by SFRP5 expression, sets of microarrays were conducted with Lin- c-kitHi Sca-1+ cells and Lin- c-kitLo Sca-1Lo IL7Rα+ CLP-enriched cells derived from adult bone marrow of SFRP5-tra...
ORGANISM(S): Mus musculus 
2014-03-20 | E-GEOD-55646 | biostudies-arrayexpress
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