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ProteomicsAn adaptive biomolecular condensation response is conserved across environmentally divergent species
Cells must sense and respond to sudden maladaptive environmental changes—stresses—to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved responses: growth arrest, a specific transcriptional response, and biomolecular condensation of protein and mRNA into structures k...
ORGANISM(S): Saccharomyces kudriavzevii ZP591 Kluyveromyces marxianus DMKU3-1042 Saccharomyces cerevisiae (Baker's yeast) 
2024-03-03 | PXD044970 | Pride
Hydrogen-deuterium exchange Yeast Condensation 
TranscriptomicsmRNA-seq of neuronal compartments with perturbed mRNA degradation machinery in mouse primary cortical neurons (mPCN)
We have perturbed mRNA degradation machinery and investigated the change in subcellular localization of mRNA in mouse primary cortical neurons (mPCNs). Mutant mPCN line harbouring a ponasteroneA-inducible heterozygous dominant-negative Caf1 (dnCaf1) was generated, separated into neuronal compartment...
ORGANISM(S): Mus musculus 
2022-11-14 | E-MTAB-11572 | biostudies-arrayexpress
ProteomicsAn adaptive biomolecular condensation response is conserved across environmentally divergent species
Cells must sense and respond to sudden maladaptive environmental changes—stresses—to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved responses: growth arrest, a specific transcriptional response, and biomolecular condensation of protein and mRNA into structures k...
ORGANISM(S): Candida albicans (Yeast) 
2024-03-03 | PXD044702 | Pride
Bimolecular condensation Yeast Dia lc-ms/ms 
GenomicGWAS of Preterm Birth

Preterm birth (PTB, born before 37 weeks of gestation) is a leading cause of neonatal mortality and post-natal morbidity. PTB affects one in nine all live births in the U.S. Notably, the highest rate of PTB occurs among African Americans (one in six). PTB is a complex trait, likely determined by ...

phs000332 | dbGaP
TranscriptomicsRNA-seq of MYC-Low and MYC-High FC-MYC Cells Following SUMOylation Inhibition with SAEi ML-792
The synthetic lethal relationship between MYC and SAE2 has been previously described in FC-MYC cells using RNAi (Littler et al., 2019). Building on this work, we conducted transcriptomic analysis on MYC-low and MYC-high cells following inhibition of SUMOylation with the SAE1/2 inhibitor, ML-792 (SAE...
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14654 | biostudies-arrayexpress
ProteomicsDire wolves were the last of an ancient New World canid lineage
Phylogenetic analysis of the extinct dire wolf was carried out to explore the relationship this species had with other Canids.
ORGANISM(S): Canis dirus 
2020-11-02 | PXD021930 | Pride
Adna Dire wolf  collagen Phylogenetics 
TranscriptomicsEctoderm specification of H1 human embryonic stem cells
In recent years, several studies have shed light into the processes that regulate epidermal specification and homeostasis. We previously showed that a broad-spectrum γ–secretase inhibitor DAPT promoted early keratinocyte specification in human embryonic stem cells triggered to undergo ectoderm speci...
ORGANISM(S): Homo sapiens 
2015-03-05 | E-GEOD-66506 | biostudies-arrayexpress
UnknownDNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains
Not available
S-SCDT-10_1038-S44318-024-00093-6 | biostudies-other
GenomicsMolecular Sub-grouping of CNS-PNET
In our study we aimed to define CNS-PNET subgroups. We performed Expression, Genotyping and/or Immunohistochemistry on 142 samples from 20 worldwide centers. Using these techniques, we have identified three molecular subgroups with distinct expression and copy number patterns, as well as, unique c...
EGAS00000000116 | EGA
UnknownEnhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.
Not available
S-EPMC11629703 | biostudies-literature
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