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MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
TranscriptomicsDRM complex mutant lin-54 vs. H3K36 methyltransferase mutant mes-4 vs. lin-54; mes-4 double mutant vs. wild type C.elegans germline
Here we uncover antagonistic regulation of transcript levels in the germline of Caenorhabditis elegans hermaphrodites. The histone methyltransferase MES-4 marks genes expressed in the germline with methylated Lys36 on histone H3 (H3K36me) and promotes their transcription; MES-4 also represses genes ...
ORGANISM(S): Caenorhabditis elegans 
2013-11-05 | E-GEOD-52064 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cells during differentiation to investigate dosage compensation by assaying expression of X-linked genes
Dosage compensation in mammals involves silencing of one X chromosome in XX females, and requires expression, in cis, of Xist silencing RNA. Using microarray analysis to assay expression of X-linked genes in mouse embryonic stem cells, we show that dosage compensation also involves global up-regulat...
ORGANISM(S): Mus musculus 
2007-10-01 | E-MEXP-1150 | biostudies-arrayexpress
TranscriptomicsRNA Seq analysis of Mefs Isolated from STC1+/+ and STC1-/- mice
Evaluation of X-linked gene expression in MEFs isolated from STC1 wild type and knock out mice X chromosome inactivation (XCI) is initiated in cis by the Xist RNA, which coats the inactive X chromosome (Xi) from which it is produced. We performed a large-scale RNA interference screen to identify tr...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-47395 | biostudies-arrayexpress
TranscriptomicsRNA-seq Analysis of MoRFX1-dependent Genes in Magnaporthe oryzae 70-15
Purpose: The goals of this study are to find out the genes regulated directly or indirectly by the regulatory factor X protein MoRfx1 by RNA-seq in the rice blast fungus Methods: Mycelial mRNAs of the wild type strain 70-15, ΔMorfx1 incubated in H2O at 25˚C for 4 h, in triplicate independently for...
ORGANISM(S): Magnaporthe oryzae 
2016-07-20 | E-GEOD-65296 | biostudies-arrayexpress
ProteomicsA conserved chronobiological complex times C. elegans development; map LIN-42 interacting proteins
The mammalian PAS-domain protein PERIOD (PER) and its C. elegans orthologue LIN-42 have been proposed to constitute an evolutionary link between two distinct, circadian and developmental, timing systems. However, while the function of PER in animal circadian rhythms is well understood molecularly an...
ORGANISM(S): Caenorhabditis elegans 
2025-10-10 | PXD058601 | Pride
Kin-20 Lin-42 Ck1bd Phosphorylation Pas-domain protein period C. elegans development 
GenomicsIdentification of Transcription Factor LIN-13::GFP Binding Regions in Embryos
modENCODE_submission_2613 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is ta...
ORGANISM(S): Caenorhabditis elegans 
2011-02-18 | E-GEOD-25804 | biostudies-arrayexpress
ProteomicsA conserved chronobiological complex times C. elegans development; map in vivo LIN-42 phosphorylation sites
The mammalian PAS-domain protein PERIOD (PER) and its C. elegans orthologue LIN-42 have been proposed to constitute an evolutionary link between two distinct, circadian and developmental, timing systems. However, while the function of PER in animal circadian rhythms is well understood molecularly an...
ORGANISM(S): Caenorhabditis elegans 
2025-10-10 | PXD058598 | Pride
Kin-20 Lin-42 Ck1bd Phosphorylation Pas-domain protein period C. elegans development 
GenomicsIdentification of Transcription Factor LIN-15B::GFP Binding Regions in L3
modENCODE_submission_2610 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is ta...
ORGANISM(S): Caenorhabditis elegans 
2011-02-18 | E-GEOD-25802 | biostudies-arrayexpress
ProteomicsRetinal Proteomic Alterations and Combined Transcriptomic-proteomic Analysis in the Early Stages Progression of a Mouse Model of X-Linked Retinoschisis
X-linked retinoschisis (XLRS) is among the most common inherited degenerative retinopathies. Functional impairment of RS1 protein is the cause of XLRS, which presents childhood onset with typical structural and functional alterations. However, the molecular mechanisms underlying RS1 malfunction rema...
ORGANISM(S): Mus Musculus 
2022-02-27 | PXD031901 |
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