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ProteomicsRetinal Proteomic Alterations and Combined Transcriptomic-proteomic Analysis in the Early Stages Progression of a Mouse Model of X-Linked Retinoschisis
X-linked retinoschisis (XLRS) is among the most common inherited degenerative retinopathies. Functional impairment of RS1 protein is the cause of XLRS, which presents childhood onset with typical structural and functional alterations. However, the molecular mechanisms underlying RS1 malfunction rema...
ORGANISM(S): Mus Musculus 
2022-02-27 | PXD031901 |
ProteomicsPoplar acetylome profiling reveals lysine acetylation dynamics in seasonal dormancy release.
Bud dormancy in perennials in boreal and temperate ecosystems is crucial for survival in harsh winter. Dormancy is released by prolonged exposure to low temperatures and is followed by reactive growth in the spring. Lysine acetylation (Kac) is one of the major post-translational modifications (PTMs)...
ORGANISM(S): Populus canescens (Grey poplar) (Populus tremula x Populus alba) 
2021-05-20 | PXD024041 | Pride
Perennial  poplar  dormancy release  lysine acetylome 
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
TranscriptomicsPCGF6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ES cells and functions in iPS reprogramming
Polycomb group (PcG) proteins comprise a large group of evolutionary conserved factors with essential roles for embryonic development and adult stem cell function. PcG proteins constitute two main multiprotein polycomb repressive complexes (PRC1 and PRC2) that operate in a hierarchical manner to sil...
ORGANISM(S): Mus musculus 
2014-09-26 | E-GEOD-56126 | biostudies-arrayexpress
ProteomicsThe genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance
Comparative proteome analysis of beaver (Castor canadensis) and mouse (Mus musculus) liver tissues
ORGANISM(S): Castor canadensis Mus musculus (Mouse) 
2022-02-16 | PXD028546 | Pride
Cancer Longevity Comparative biology Aging 
ProteomicsLD4172 and LD4172NC treated MDA_MB_231 cell line global proteomics
1 million MDAMB231 cells were seeded in 6-well plates. On the following day, MBAMB231 cells were treated in triplicates with DMSO, LD4172 (100 nM) or LD4172-NC (100 nM) for 6 hours. Cells were washed with ice-cold PBS three times. The cell pellets were lysed, reduced, alkylated, and digested by Easy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-05 | MSV000092348 | MassIVE
ProteomicsLD4172 100nM and LD4172NC 100nM treated MDA_MB_231 cell line global proteomics
1 million MDAMB231 cells were seeded in 6-well plates. On the following day, MBAMB231 cells were treated in triplicates with DMSO, LD4172 (100 nM) or LD4172-NC (100 nM) for 6 hours. Cells were washed with ice-cold PBS three times. The cell pellets were lysed, reduced, alkylated, and digested by Easy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-07 | MSV000092377 | MassIVE
UnknownGenomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.
Not available
S-EPMC8656434 | biostudies-literature
ProteomicsThe deubiquitinase USP13 maintains cancer cell stemness by promoting FASN stability in small cell lung cancer
USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. However, the functional role of USP13 in small cell lung cancer (SCLC) remains largely unclear. In this study, we found that the deubiquitinase USP13 is highly expressed in SCLC tumor samples and...
ORGANISM(S): Homo Sapiens 
PXD032993 |
ProteomicsFunctional identification of protocadherin alpha 9 (PCDHA9) as a candidate causative gene for amyotrophic lateral sclerosis
Mice were sacrificed after anesthesia by isoflurane following neck cutting. The spinal cord L3-L5 was taken and frozen in liquid nitrogen immediately and the ventral horn of the bilateral spinal cord (about 400um thick in gray matter area) was collected at low temperature. The samples were digested ...
ORGANISM(S): Mus Musculus 
PXD042929 |
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