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TranscriptomicsWidespread regulation of translation by elongation pausing in heat shock
RNA-seq and ribosome footprinting libraries of mouse 3T3 and human 293T cellsrelated to Shalgi et al. 2013 36bases paired-end RNA-seq, and ribosome footprinting libraries for: 3T3 cells - Control, 8 hours of mild heat shock (42) and 2 hours of severe heat shock (44) - in replicates, as well as 3T3 ...
ORGANISM(S): Mus musculus 
2013-01-03 | E-GEOD-32060 | biostudies-arrayexpress
ProteomicsThe Parkinson's disease protein alpha-synuclein is a direct modulator of Processing-bodies and mRNA stability
Hallacli E, Kayatekin C, Nazeen S, Wang XH, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney MT, Felsky D, Sandoe J, Vahdatshoar A, Udeshi ND, Mani DR,Carr SA, de Jager P, Myers CL, Lindquist S, Greenmyre TJ, Bartel DP, Feany MB, Sunyaev S, Chung CY and Khurana V. Alp...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-09 | MSV000089026 | MassIVE
TranscriptomicsHSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [gene expression]
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tra...
ORGANISM(S): Homo sapiens 
2012-08-06 | E-GEOD-38232 | biostudies-arrayexpress
GenomicsHSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq]
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tra...
ORGANISM(S): Homo sapiens 
2012-08-07 | E-GEOD-38901 | biostudies-arrayexpress
UnknownHSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.
Not available
S-EPMC4280614 | biostudies-literature
GenomicsTight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [ChIP-Seq]
A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through ...
ORGANISM(S): Homo sapiens 
2013-07-21 | E-GEOD-45852 | biostudies-arrayexpress
UnknownAPOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response.
Not available
S-EPMC7646253 | biostudies-literature
ProteomicsTaipale_HSP90_cochaperone_P77_VS3
This submission is part of the mass spectrometry datasets for the manuscript by Taipale et al. (HSP90 cochaperone interaction network). This submission contains files for the second batch (2012) of the files included in the manuscript, all acquired on a 5600 TripleTOF mass spectrometer. See the RE...
2013-08-02 | MSV000078465 | MassIVE
ProteomicsTaipale_HSP90_cochaperone_P77_VS1
This submission is part of the mass spectrometry datasets for the manuscript by Taipale et al. (HSP90 cochaperone interaction network). This submission contains files for the first batch (2011) of the files included in the manuscript, all acquired on a 5600 TripleTOF mass spectrometer. See the RE...
2013-08-02 | MSV000078466 | MassIVE
ProteomicsTaipale_HSP90_cochaperone_P77_VS6
This submission is part of the mass spectrometry datasets for the manuscript by Taipale et al. (HSP90 cochaperone interaction network); Cell, 2014. This submission contains files for the data presented as a supplementary figure that details the interaction profiles for Kelch family proteins, all ac...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-04-02 | MSV000078575 | MassIVE
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